Linked Life Data

12823632

Source:http://linkedlifedata.com/resource/pubmed/id/12823632

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pubmed-article:12823632pubmed:abstractTextWe examined relationships among cerebrospinal fluid (CSF) concentrations of the major serotonin metabolite (5-HIAA, 5-hydroxyindoleacetic acid) and significant medical and behavioral outcomes for female rhesus macaques. Based on earlier findings with males we predicted that low CSF 5-HIAA concentrations would be associated with a range of negative life history outcomes in our captive specific-pathogen-free (SPF) breeding colony. We found that the mean CSF 5-HIAA concentration among animals that died over the course of the study period was significantly lower than among animals that survived. Further examination indicated an inverse relationship between CSF 5-HIAA concentration and number of treatments for illness, further suggesting a link between serotonergic functioning and overall animal health. Examination of behavioral data indicated that individuals with low CSF 5-HIAA concentrations were more often the targets of aggressive bouts than were individuals with high CSF 5-HIAA concentrations. Finally, we found a positive relationship between CSF 5-HIAA concentration and infant survivorship. These results suggest negative life history consequences of impaired serotonergic functioning in captive female rhesus macaques, and indicate that CSF 5-HIAA concentration sampled early in life may provide a useful tool in facilitating colony management decisions concerning utilization of scarce and increasingly valuable non-human primate resources.lld:pubmed
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pubmed-article:12823632pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:12823632pubmed:articleTitleCSF 5-HIAA concentration as an early screening tool for predicting significant life history outcomes in female specific-pathogen-free (SPF) rhesus macaques (Macaca mulatta) maintained in captive breeding groups.lld:pubmed
pubmed-article:12823632pubmed:affiliationDivision of Research and Development, LABS of Virginia, Inc., 95 Castle Hall Road, PO Box 557, Yemassee, SC 29945, USA. gwprimate@netscape.netlld:pubmed
pubmed-article:12823632pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12823632pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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