| pubmed-article:12821646 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:12821646 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:12821646 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12821646 | pubmed:dateCreated | 2003-6-24 | lld:pubmed |
| pubmed-article:12821646 | pubmed:abstractText | Transmembrane isoforms of neuregulin-1 (Nrg-1), ligands for erbB receptors, include an extracellular domain with an EGF-like sequence and a highly conserved intracellular domain (ICD) of unknown function. In this paper, we demonstrate that transmembrane isoforms of Nrg-1 are bidirectional signaling molecules in neurons. The stimuli for Nrg-1 back signaling include binding of erbB receptor dimers to the extracellular domain of Nrg-1 and neuronal depolarization. These stimuli elicit proteolytic release and translocation of the ICD of Nrg-1 to the nucleus. Once in the nucleus, the Nrg-1 ICD represses expression of several regulators of apoptosis, resulting in decreased neuronal cell death in vitro. Thus, regulated proteolytic processing of Nrg-1 results in retrograde signaling that appears to mediate contact and activity-dependent survival of Nrg-1-expressing neurons. | lld:pubmed |
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| pubmed-article:12821646 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12821646 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12821646 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12821646 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12821646 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12821646 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:12821646 | pubmed:author | pubmed-author:RoleLorna WLW | lld:pubmed |
| pubmed-article:12821646 | pubmed:author | pubmed-author:TalmageDavid... | lld:pubmed |
| pubmed-article:12821646 | pubmed:author | pubmed-author:BaoJianxinJ | lld:pubmed |
| pubmed-article:12821646 | pubmed:author | pubmed-author:WolpowitzDeon... | lld:pubmed |
| pubmed-article:12821646 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12821646 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12821646 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:12821646 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12821646 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12821646 | pubmed:pagination | 1133-41 | lld:pubmed |
| pubmed-article:12821646 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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