| pubmed-article:12819188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C0682560 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C0007131 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12819188 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12819188 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12819188 | pubmed:dateCreated | 2003-9-8 | lld:pubmed |
| pubmed-article:12819188 | pubmed:abstractText | To help identify genes, which may regulate metastasis in lung cancer, we performed representational difference analysis between a patient-derived non-small cell lung carcinoma (NSCLC) and immortalized normal human bronchial epithelial cells. This analysis revealed that bone morphogenetic proteins-2/4 (BMP) mRNA was expressed in the lung carcinoma. BMP-2/4 are known to induce pluripotent cell differentiation, enhance cell migration and stimulate proliferation during embryonic development. Despite being powerful morphogens it is not known whether BMP-2/4 have significant biological activity in human carcinomas. Furthermore, it has not been established whether the mature active BMP-2/4 protein is aberrantly expressed in patient-derived tumors. The purpose of this study was to determine whether the expression of the mature BMP-2/4 protein is disregulated in human lung carcinomas and to establish whether it has adverse biological activity. This study reveals that the mature BMP-2 protein, but not BMP-4, is highly over-expressed in human NCSLC with little to no expression in normal lung tissue or benign lung tumors. The expression of BMP-2 localized specifically to the cancer cells. Recombinant BMP-2 stimulated in vitro, the migration and invasiveness of the A549 and H7249 human lung cancer cell lines. In vivo, recombinant BMP-2 enhanced the growth of tumors formed from A549 cells injected subcutaneously into nude mice. Furthermore, inhibition of BMP-2 activity with either recombinant noggin or anti-BMP-2 antibody resulted in a significant reduction in tumor growth. This study shows that expression of the mature BMP-2 protein is disregulated in the majority of NSCLC. BMP-2 enhancement of tumor cell migration and invasion, as well as stimulating tumor growth in vivo, suggests it has important biological activity in lung carcinomas. | lld:pubmed |
| pubmed-article:12819188 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12819188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12819188 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12819188 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:CalvanoSteve... | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:LowryStephen... | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:LangenfeldEla... | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:Abou-NuktaFad... | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:AmentaPeterP | lld:pubmed |
| pubmed-article:12819188 | pubmed:author | pubmed-author:LangenfeldJoh... | lld:pubmed |
| pubmed-article:12819188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12819188 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:12819188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12819188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12819188 | pubmed:pagination | 1445-54 | lld:pubmed |
| pubmed-article:12819188 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:meshHeading | pubmed-meshheading:12819188... | lld:pubmed |
| pubmed-article:12819188 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12819188 | pubmed:articleTitle | The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. | lld:pubmed |
| pubmed-article:12819188 | pubmed:affiliation | Department of Surgery, Division of Thoracic Surgery, UMDNJ-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, PO Box 19, New Brunswick, NJ 08903-0019, USA. langenje@umdnj.edu | lld:pubmed |
| pubmed-article:12819188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12819188 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12819188 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:650 | entrezgene:pubmed | pubmed-article:12819188 | lld:entrezgene |
| entrez-gene:659 | entrezgene:pubmed | pubmed-article:12819188 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12819188 | lld:entrezgene |
| lhgdn:association:17456 | lhgdn:found_in | pubmed-article:12819188 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12819188 | lld:pubmed |
