| pubmed-article:12816483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12816483 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:12816483 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:12816483 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:12816483 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:12816483 | pubmed:dateCreated | 2003-6-20 | lld:pubmed |
| pubmed-article:12816483 | pubmed:abstractText | The palladium-catalyzed arylation of alpha,alpha-disubstituted arylmethanols with aryl halides proceeds not only via C-H bond cleavage at the ortho-position, but also via cleavage of the sp(2)-sp(3) C-C bond with the liberation of ketones (beta-carbon elimination) to give the corresponding biaryls. Both reactions appear to occur through common arylpalladium(II) alcoholate intermediates. The results of systematic studies with respect to which C-C or C-H bond is preferentially cleaved in the arylation are reported. Among the important findings is the selective elimination of ortho-substituted aryl groups even from aryl(diphenyl)methanols due to steric reasons. Thus, various biaryls having ortho-substituents can be produced efficiently by treatment of the corresponding aryl(diphenyl or dimethyl)methanols with aryl bromides and chlorides. | lld:pubmed |
| pubmed-article:12816483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12816483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12816483 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:12816483 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12816483 | pubmed:issn | 0022-3263 | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:SatohTetsuyaT | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:MiuraMasahiro... | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:NomuraMasakat... | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:TeraoYoshitoY | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:WakuiHiroyuki... | lld:pubmed |
| pubmed-article:12816483 | pubmed:author | pubmed-author:NomotoMichiyo... | lld:pubmed |
| pubmed-article:12816483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12816483 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:12816483 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:12816483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12816483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12816483 | pubmed:pagination | 5236-43 | lld:pubmed |
| pubmed-article:12816483 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12816483 | pubmed:articleTitle | Palladium-catalyzed arylation of alpha,alpha-disubstituted arylmethanols via cleavage of a C-C or a C-H bond to give biaryls. | lld:pubmed |
| pubmed-article:12816483 | pubmed:affiliation | Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:12816483 | pubmed:publicationType | Journal Article | lld:pubmed |
