| pubmed-article:1281285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C1413208 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:1281285 | lifeskim:mentions | umls-concept:C1291775 | lld:lifeskim |
| pubmed-article:1281285 | pubmed:issue | 6404 | lld:pubmed |
| pubmed-article:1281285 | pubmed:dateCreated | 1993-1-12 | lld:pubmed |
| pubmed-article:1281285 | pubmed:abstractText | Molecules encoded by the human CD1 locus on chromosome 1 (ref. 33) are recognized by selected CD4-8- T-cell clones expressing either alpha beta or gamma delta T-cell antigen receptors. The known structural resemblance of CD1 molecules to antigen-presenting molecules encoded by major histocompatibility complex (MHC) genes on human chromosome 6 (refs 3, 4, 34, 35), suggested that CD1 may represent a family of antigen-presenting molecules separate from those encoded in the MHC. Here we report that the proliferative and cytotoxic responses of human CD4-8- alpha beta TCR+ T cells specific for Mycobacterium tuberculosis can be restricted by CD1b, one of the four identified protein products of the CD1 locus. The responses of these T cells to M. tuberculosis seemed not to involve MHC encoded molecules, but were absolutely dependent on the expression of CD1b by the antigen-presenting cell and involved an antigen processing requirement similar to that seen in MHC class II-restricted antigen presentation. These results provide, to our knowledge, the first direct evidence for the proposed antigen-presenting function of CD1 molecules and suggest that the CD1 family plays a role in cell-mediated immunity to microbial pathogens. | lld:pubmed |
| pubmed-article:1281285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1281285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1281285 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1281285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1281285 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1281285 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1281285 | pubmed:author | pubmed-author:MoritaC TCT | lld:pubmed |
| pubmed-article:1281285 | pubmed:author | pubmed-author:PorcelliSS | lld:pubmed |
| pubmed-article:1281285 | pubmed:author | pubmed-author:BrennerM BMB | lld:pubmed |
| pubmed-article:1281285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1281285 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:1281285 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:1281285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1281285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1281285 | pubmed:pagination | 593-7 | lld:pubmed |
| pubmed-article:1281285 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1281285 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1281285 | pubmed:articleTitle | CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. | lld:pubmed |
| pubmed-article:1281285 | pubmed:affiliation | Department of Rheumatology/Immunology, Brigham and Women's Hospital, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:1281285 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1281285 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1281285 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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