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pubmed-article:12808081pubmed:abstractTextThe virulence of leptospires isolated from human patients against C3H/HeJ mice was investigated. Infection with clinical isolates from patients with severe leptospirosis was lethal to C3H/HeJ mice, suggesting that C3H/HeJ mice are suitable as an acute lethal model of severe leptospirosis. Using this model, a novel antigen of pathogenic Leptospira spp. (named LAg42), which reacted with convalescent mice sera, was identified. LAg42 is a 42 kDa inner-membrane protein and its immunogenic region is located in the C-terminal region. The gene for LAg42 is conserved among pathogenic leptospires but not among non-pathogenic leptospires, which suggests its involvement in virulence.lld:pubmed
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pubmed-article:12808081pubmed:articleTitleIdentification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera.lld:pubmed
pubmed-article:12808081pubmed:affiliationDepartment of Bacteriology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.lld:pubmed
pubmed-article:12808081pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12808081pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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