| pubmed-article:1279982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0027028 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0001041 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1279982 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1279982 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:1279982 | pubmed:dateCreated | 1992-12-23 | lld:pubmed |
| pubmed-article:1279982 | pubmed:abstractText | This study sought to characterize the action of neurokinin B (NKB) and senktide, a selective synthetic agonist for NK3 receptors, on the myenteric plexus of the guinea pig small intestine. Both peptides stimulated a dose-dependent release of [3H]-acetylcholine (ACh). The mean effective dose values were 1 x 10(-9) for NKB and 3 x 10(-11) M for senktide. The action of these two neurokinins was blocked by the removal of Ca2+ and was sensitive to tetrodotoxin. The release of [3H]ACh was antagonized by omega-conotoxin GVIA, implying the involvement of N-type voltage-sensitive calcium channels. Senktide-evoked ACh release was also insensitive to nifedipine or flunarizine but was blocked by diltiazem. Treatment with protein kinase C (PKC) inhibitors (H-7 and polymyxin B) or activators (12-tetradecanoylphorbol 13-acetate and SC-9) failed to alter the NK3 receptor-mediated ACh output. Our data did not support an action mediated via PKC upon the activation of NK3 receptors on myenteric cholinergic neurons. | lld:pubmed |
| pubmed-article:1279982 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1279982 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1279982 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1279982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1279982 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1279982 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1279982 | pubmed:author | pubmed-author:MandelK GKG | lld:pubmed |
| pubmed-article:1279982 | pubmed:author | pubmed-author:YauW MWM | lld:pubmed |
| pubmed-article:1279982 | pubmed:author | pubmed-author:YoutherM LML | lld:pubmed |
| pubmed-article:1279982 | pubmed:author | pubmed-author:DorsettJ AJA | lld:pubmed |
| pubmed-article:1279982 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1279982 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:1279982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1279982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1279982 | pubmed:pagination | G659-64 | lld:pubmed |
| pubmed-article:1279982 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1279982 | pubmed:meshHeading | pubmed-meshheading:1279982-... | lld:pubmed |
| pubmed-article:1279982 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1279982 | pubmed:articleTitle | Neurokinin3 receptor regulation of acetylcholine release from myenteric plexus. | lld:pubmed |
| pubmed-article:1279982 | pubmed:affiliation | Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901-6512. | lld:pubmed |
| pubmed-article:1279982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1279982 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1279982 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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