| pubmed-article:12799443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C0013570 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C0028630 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C2700592 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C0079941 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C1332704 | lld:lifeskim |
| pubmed-article:12799443 | lifeskim:mentions | umls-concept:C1265875 | lld:lifeskim |
| pubmed-article:12799443 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12799443 | pubmed:dateCreated | 2003-6-11 | lld:pubmed |
| pubmed-article:12799443 | pubmed:abstractText | mRNAs containing premature translation termination codons (nonsense mRNAs) are targeted for deadenylation-independent degradation in a mechanism that depends on Upf1p, Upf2p and Upf3p. This decay pathway is often called nonsense- mediated mRNA decay (NMD). Nonsense mRNAs are decapped by Dcp1p and then degraded 5' to 3' by Xrn1p. In the yeast Saccharomyces cerevisiae, a significant number of wild-type mRNAs accumulate in upf mutants. Wild-type PPR1 mRNA is one of these mRNAs. Here we show that PPR1 mRNA degradation depends on the Upf proteins, Dcp1p, Xrn1p and Hrp1p. We have mapped an Upf1p-dependent destabilizing element to a region located within the 5'-UTR and the first 92 bases of the PPR1 ORF. This element targets PPR1 mRNA for Upf-dependent decay by a novel mechanism. | lld:pubmed |
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| pubmed-article:12799443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12799443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12799443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12799443 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12799443 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:12799443 | pubmed:author | pubmed-author:TaylorRR | lld:pubmed |
| pubmed-article:12799443 | pubmed:author | pubmed-author:AtkinA LAL | lld:pubmed |
| pubmed-article:12799443 | pubmed:author | pubmed-author:KebaaraBB | lld:pubmed |
| pubmed-article:12799443 | pubmed:author | pubmed-author:NazarenusTT | lld:pubmed |
| pubmed-article:12799443 | pubmed:author | pubmed-author:ForchAA | lld:pubmed |
| pubmed-article:12799443 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12799443 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12799443 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:12799443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12799443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12799443 | pubmed:pagination | 3157-65 | lld:pubmed |
| pubmed-article:12799443 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12799443 | pubmed:meshHeading | pubmed-meshheading:12799443... | lld:pubmed |
| pubmed-article:12799443 | pubmed:meshHeading | pubmed-meshheading:12799443... | lld:pubmed |
| pubmed-article:12799443 | pubmed:meshHeading | pubmed-meshheading:12799443... | lld:pubmed |
