| pubmed-article:12796490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0386482 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12796490 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12796490 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:12796490 | pubmed:dateCreated | 2003-8-11 | lld:pubmed |
| pubmed-article:12796490 | pubmed:abstractText | The P2X7 receptor, mainly expressed by immune cells, is a ionotropic receptor activated by high concentration of extracellular ATP. It is involved in several processes relevant to immunomodulation and inflammation. Among these processes, the production of extracellular interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, plays a major role in the activation of the cytokine network. We have investigated the role of P2X7 receptor and of an associated calcium-activated potassium conductance (BK channels) in IL-1beta maturation and releasing processes by Schwann cells. Lipopolysaccharide-primed Schwann cells synthesized large amounts of pro-IL-1beta but did not release detectable amounts of pro or mature IL-1beta. ATP on its own had no effect on the synthesis of pro-IL-1beta, but a co-treatment with lipopolysaccharide and ATP led to the maturation and the release of IL-1beta by Schwann cells. Both mechanisms were blocked by oxidized ATP. IL-1beta-converting enzyme (ICE), the caspase responsible for the maturation of pro-IL-1beta in IL-1beta, was activated by P2X7 receptor stimulation. The specific inhibition of ICE by the caspase inhibitor Ac-Tyr-Val-Ala-Asp-aldehyde blocked the maturation of IL-1beta. In searching for a link between the P2X7 receptor and the activation of ICE, we found that enhancing potassium efflux from Schwann cells upregulated the production of IL-1beta, while strongly reducing potassium efflux led to opposite effects. Blocking BK channels actually modulated IL-1beta release. Taken together, these results show that P2X7 receptor stimulation and associated BK channels, through the activation of ICE, leads to the maturation and the release of IL-1beta by immune-challenged Schwann cells. | lld:pubmed |
| pubmed-article:12796490 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12796490 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796490 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12796490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12796490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12796490 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12796490 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:ParnetPatrici... | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:MédinaChantal... | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:ColomarAurore... | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:MartyVincentV | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:CombeChantalC | lld:pubmed |
| pubmed-article:12796490 | pubmed:author | pubmed-author:AmédéeThierry... | lld:pubmed |
| pubmed-article:12796490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12796490 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12796490 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12796490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12796490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12796490 | pubmed:pagination | 30732-40 | lld:pubmed |
| pubmed-article:12796490 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12796490 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12796490 | pubmed:articleTitle | Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors. | lld:pubmed |
| pubmed-article:12796490 | pubmed:affiliation | Département de Physiologie, Centre de Recherches en Sciences Neurologiques, Université de Montréal, Montréal H3C 3J7, Canada. | lld:pubmed |
| pubmed-article:12796490 | pubmed:publicationType | Journal Article | lld:pubmed |
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