| pubmed-article:12796482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C1424222 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C1955321 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:12796482 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:12796482 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:12796482 | pubmed:dateCreated | 2003-8-11 | lld:pubmed |
| pubmed-article:12796482 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796482 | pubmed:abstractText | DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 is related to male fertility, and its level in sperm decreases in response to exposure to sperm toxicants. DJ-1 has also been identified as a hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found to be responsible for familial Parkinson's disease. Here, we present the crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1 forms a dimer in the crystal, and the monomer takes a flavodoxin-like Rossmann-fold. DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii, and belongs to the Class I glutamine amidotransferase-like superfamily. However, DJ-1 contains an additional alpha-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1 and appears to regulate the enzymatic activity. DJ-1 may induce conformational changes to acquire catalytic activity in response to oxidative stress. | lld:pubmed |
| pubmed-article:12796482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12796482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12796482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12796482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12796482 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12796482 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:ArigaHiroyosh... | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:InagakiFuyuhi... | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:HoriuchiMasat... | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:NikiTakeshiT | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:TairaTakahiro... | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:SuzukiNobuo... | lld:pubmed |
| pubmed-article:12796482 | pubmed:author | pubmed-author:HonbouKazuyaK | lld:pubmed |
| pubmed-article:12796482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12796482 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12796482 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12796482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12796482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12796482 | pubmed:pagination | 31380-4 | lld:pubmed |
| pubmed-article:12796482 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12796482 | pubmed:meshHeading | pubmed-meshheading:12796482... | lld:pubmed |
| pubmed-article:12796482 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12796482 | pubmed:articleTitle | The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. | lld:pubmed |
| pubmed-article:12796482 | pubmed:affiliation | Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo, 060-0812, Japan. | lld:pubmed |
| pubmed-article:12796482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12796482 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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