| pubmed-article:12792655 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:12792655 | lifeskim:mentions | umls-concept:C0205126 | lld:lifeskim |
| pubmed-article:12792655 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:12792655 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:12792655 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:12792655 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:12792655 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12792655 | pubmed:dateCreated | 2003-6-6 | lld:pubmed |
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| pubmed-article:12792655 | pubmed:abstractText | The screening of new antibiotics against several bacterial strains often reveals unexpected occurrences of natural drug resistance. Two examples of this involve specific inhibitors of Staphylococcus aureus isoleucyl-transfer-RNA synthetase 1 (IleRS1) and, more recently, Streptococcus pneumoniae methionyl-tRNA synthetase 1 (MetRS1). In both cases, resistance is due to the presence of a second gene that encodes another synthetase (IleRS2 or MetRS2). Here, we show that both S. pneumoniae MetRS2 and S. aureus IleRS2 have closely related homologues in the Gram-positive bacterium Bacillus anthracis, the causative agent of anthrax. Furthermore, similar to drug-resistant pathogens, strains of B. anthracis and its closest relative, B. cereus, also have wild-type ileS1 and metS1 genes. Clostridium perfringens, the causative agent of gangrene, also has two metS genes, whereas Oceanobacillus iheyensis isolated from deep-sea sediments has a single ileS2-type gene. This study shows the importance of understanding complex evolutionary networks of ancient horizontal gene transfer for the development of novel antibiotics. | lld:pubmed |
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| pubmed-article:12792655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12792655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792655 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12792655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12792655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12792655 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12792655 | pubmed:issn | 1469-221X | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:StanhopeMicha... | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:BrownJames... | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:GentryDanielD | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:HolmesDavid... | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:BeckerJulie... | lld:pubmed |
| pubmed-article:12792655 | pubmed:author | pubmed-author:IngrahamKaren... | lld:pubmed |
| pubmed-article:12792655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12792655 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12792655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12792655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12792655 | pubmed:pagination | 692-8 | lld:pubmed |
| pubmed-article:12792655 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12792655 | pubmed:meshHeading | pubmed-meshheading:12792655... | lld:pubmed |
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| pubmed-article:12792655 | pubmed:meshHeading | pubmed-meshheading:12792655... | lld:pubmed |
| pubmed-article:12792655 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12792655 | pubmed:articleTitle | Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens. | lld:pubmed |
| pubmed-article:12792655 | pubmed:affiliation | Bioinformatics Division, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, Collegeville, Pennsylvania 19426, USA. | lld:pubmed |
| pubmed-article:12792655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12792655 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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