| pubmed-article:12790191 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0037638 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0152058 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0812409 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C1883073 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:12790191 | lifeskim:mentions | umls-concept:C1589268 | lld:lifeskim |
| pubmed-article:12790191 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12790191 | pubmed:dateCreated | 2003-6-6 | lld:pubmed |
| pubmed-article:12790191 | pubmed:abstractText | A solvent compensation method based on flow injection analysis is used to obtain high quality nuclear magnetic resonance (NMR) spectra during solvent gradients. Using a binary solvent system containing D2O and CD3OD, NMR line broadening and chemical shift changes are observed with a 10% methanol per min solvent composition gradient. However, by creating a second equal but reverse gradient and combining the two solvent gradients before the NMR detector, the composition of solvent reaching the NMR flow cell is kept constant. We demonstrate a system using flow injection analysis of combining solvent gradients and show constant NMR spectral performance as a function of time as the combined flow has a constant solvent composition irrespective of the initial solvent gradient. Using this approach, methods can be developed to measure high quality NMR spectra during on-flow gradient LC-NMR experiments. The ultimate ability of this approach depends on the ability to compensate for the disturbance of the solvent gradient and reverse gradient by a pair of LC columns (the analytical and reverse gradient columns). | lld:pubmed |
| pubmed-article:12790191 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12790191 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12790191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12790191 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12790191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12790191 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12790191 | pubmed:month | May | lld:pubmed |
| pubmed-article:12790191 | pubmed:issn | 0003-2654 | lld:pubmed |
| pubmed-article:12790191 | pubmed:author | pubmed-author:SweedlerJonat... | lld:pubmed |
| pubmed-article:12790191 | pubmed:author | pubmed-author:WoltersAndrew... | lld:pubmed |
| pubmed-article:12790191 | pubmed:author | pubmed-author:JayawickramaD... | lld:pubmed |
| pubmed-article:12790191 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12790191 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:12790191 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12790191 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12790191 | pubmed:pagination | 421-6 | lld:pubmed |
| pubmed-article:12790191 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12790191 | pubmed:meshHeading | pubmed-meshheading:12790191... | lld:pubmed |
| pubmed-article:12790191 | pubmed:meshHeading | pubmed-meshheading:12790191... | lld:pubmed |
| pubmed-article:12790191 | pubmed:meshHeading | pubmed-meshheading:12790191... | lld:pubmed |
| pubmed-article:12790191 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12790191 | pubmed:articleTitle | Mobile phase compensation to improve NMR spectral properties during solvent gradients. | lld:pubmed |
| pubmed-article:12790191 | pubmed:affiliation | Department of Chemistry and the Beckman Institute, University of Illinois, Urbana, IL 61801, USA. | lld:pubmed |
| pubmed-article:12790191 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12790191 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12790191 | lld:pubmed |
