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pubmed-article:12788624pubmed:abstractTextThe baculovirus-insect cell expression system is widely used to produce recombinant glycoproteins for many different biomedical applications. However, due to the fundamental nature of insect glycoprotein processing pathways, this system is typically unable to produce recombinant mammalian glycoproteins with authentic oligosaccharide side chains. This minireview summarizes our current understanding of insect protein glycosylation pathways and our recent efforts to address this problem. These efforts have yielded new insect cell lines and baculoviral vectors that can produce recombinant glycoproteins with humanized oligosaccharide side chains.lld:pubmed
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pubmed-article:12788624pubmed:articleTitleDeveloping baculovirus-insect cell expression systems for humanized recombinant glycoprotein production.lld:pubmed
pubmed-article:12788624pubmed:affiliationDepartment of Molecular Biology, University of Wyoming, P.O. Box 3944, Laramie, WY 82071-3944, USA. DLJarvis@uwyo.edulld:pubmed
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