| pubmed-article:12784265 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12784265 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:12784265 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12784265 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:12784265 | lifeskim:mentions | umls-concept:C0449445 | lld:lifeskim |
| pubmed-article:12784265 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12784265 | pubmed:dateCreated | 2003-6-4 | lld:pubmed |
| pubmed-article:12784265 | pubmed:abstractText | The identification of pathogenic mutations in the three genes alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) has elucidated the ubiquitin proteasome system (UPS) and its potential role as a causal pathway in Parkinson's disease (PD). In addition, polymorphisms of these three genes have been shown to be independently associated with PD. In a sample of 298 unrelated PD cases and 185 controls, we applied a two-phased approach of recursive partitioning and logistic regression analyses to explore complex interactions. For women only, we observed an epistatic interaction of UCHL1 and alpha-synuclein genotypes with significant effects on PD risk (odds ratio = 2.42; P = 0.003). Our findings are consistent with the hypothesis that PD is a multigenic disorder of the UPS. | lld:pubmed |
| pubmed-article:12784265 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12784265 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12784265 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12784265 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12784265 | pubmed:issn | 0885-3185 | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:BowerJames... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:MaraganoreDem... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:RoccaWalter... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:LesnickTimoth... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:FarrerMatthew... | lld:pubmed |
| pubmed-article:12784265 | pubmed:author | pubmed-author:HardyJohn AJA | lld:pubmed |
| pubmed-article:12784265 | pubmed:copyrightInfo | Copyright 2003 Movement Disorder Society | lld:pubmed |
| pubmed-article:12784265 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12784265 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:12784265 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12784265 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12784265 | pubmed:pagination | 631-6 | lld:pubmed |
| pubmed-article:12784265 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:meshHeading | pubmed-meshheading:12784265... | lld:pubmed |
| pubmed-article:12784265 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12784265 | pubmed:articleTitle | Complex interactions in Parkinson's disease: a two-phased approach. | lld:pubmed |
| pubmed-article:12784265 | pubmed:affiliation | Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. dmaraganore@mayo.edu | lld:pubmed |
| pubmed-article:12784265 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12784265 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12784265 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5071 | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| entrez-gene:6622 | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| entrez-gene:7345 | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12784265 | lld:entrezgene |
| lhgdn:association:15292 | lhgdn:found_in | pubmed-article:12784265 | lld:lhgdn |
| lhgdn:association:25514 | lhgdn:found_in | pubmed-article:12784265 | lld:lhgdn |
| lhgdn:association:31855 | lhgdn:found_in | pubmed-article:12784265 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12784265 | lld:pubmed |
