| pubmed-article:12782677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C0376558 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12782677 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12782677 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12782677 | pubmed:dateCreated | 2003-6-3 | lld:pubmed |
| pubmed-article:12782677 | pubmed:abstractText | Immunization of newborns against viral infections may be hampered by ineffective CD8(+) T cell responses. To characterize the function of CD8(+) T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infection. We demonstrate that HCMV infection in utero leads to the expansion and the differentiation of mature HCMV-specific CD8(+) T cells, which have similar characteristics to those detected in adults. High frequencies of HCMV-specific CD8(+) T cells were detected by ex vivo tetramer staining as early as after 28 weeks of gestation. During the acute phase of infection, these cells had an early differentiation phenotype (CD28(-)CD27(+)CD45RO(+), perforin(low)), and they acquired a late differentiation phenotype (CD28(-)CD27(-)CD45RA(+), perforin(high)) during the course of the infection. The differentiated cells showed potent perforin-dependent cytolytic activity and produced antiviral cytokines. The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens. | lld:pubmed |
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| pubmed-article:12782677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12782677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12782677 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12782677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12782677 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12782677 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:LiesnardCorin... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:McMichaelAndr... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:KiddMichaelM | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:WhittleHilton... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:McAdamKeith... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:MarchantArnau... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:AppayVictorV | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:Rowland-Jones... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:KayeSteveS | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:CerundoloVinc... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:CallanMargare... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:GillespieGera... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:DulphyNicolas... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:DonnerCatheri... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:Van Der... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:OjuolaOlubuko... | lld:pubmed |
| pubmed-article:12782677 | pubmed:author | pubmed-author:Vargas... | lld:pubmed |
| pubmed-article:12782677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12782677 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:12782677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12782677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12782677 | pubmed:pagination | 1747-55 | lld:pubmed |
| pubmed-article:12782677 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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