pubmed-article:12782020 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0027051 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
pubmed-article:12782020 | lifeskim:mentions | umls-concept:C0388640 | lld:lifeskim |
pubmed-article:12782020 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:12782020 | pubmed:dateCreated | 2003-6-3 | lld:pubmed |
pubmed-article:12782020 | pubmed:abstractText | TNF-alpha is a proinflammatory cytokine, abundantly expressed after myocardial infarction. It has been suggested that it exhibits myocardial suppressive and cytotoxic effects. AG-556 is a tyrosine kinase inhibitor synthesized based on its ability to reduce TNF-alpha production and cell toxicity, and to improve experimental models mediated by TNF-alpha (i.e., peritontitis and experimental autoimmune encephalomyelitis). Daily, for 7 days, rats were injected ip with either AG-556 dissolved in DMSO or with the control vehicle. Infarct size was determined in the hearts as well as in fibrous scar formation. Cardiac TNF-alpha expression was evaluated by ELISA and immunohistochemistry. Functional hemodynamic parameters were evaluated employing echocardiography prior to sacrifice. AG-556 treatment reduced MI size at 7 days with a parallel effect on fibrous tissue formation. TNF-alpha production by splenocytes was reduced upon AG-556 treatment, whereas no differences were evident between the groups with regard to myocardial cytokine expression. AG-556 attenuated the decrease in fractional shortening at the expense of preserving end systolic diameter. AG-556 has proven beneficial in reducing myocardial infarct size and attenuated consequent hemodynamic deterioration in the rat model. If reconfirmed, AG-556 may be of potential clinical use in post-MI patients. | lld:pubmed |
pubmed-article:12782020 | pubmed:language | eng | lld:pubmed |
pubmed-article:12782020 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12782020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12782020 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12782020 | pubmed:month | Jun | lld:pubmed |
pubmed-article:12782020 | pubmed:issn | 0014-4800 | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:GeorgeJacobJ | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:KerenGadG | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:LevitzkiAlexa... | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:GoldbergIrisI | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:KerenPninaP | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:RothArieA | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:BarshackIrisI | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:BinerSimonS | lld:pubmed |
pubmed-article:12782020 | pubmed:author | pubmed-author:SherezJackJ | lld:pubmed |
pubmed-article:12782020 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12782020 | pubmed:volume | 74 | lld:pubmed |
pubmed-article:12782020 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12782020 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12782020 | pubmed:pagination | 314-8 | lld:pubmed |
pubmed-article:12782020 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:12782020 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:12782020 | pubmed:articleTitle | Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. | lld:pubmed |
pubmed-article:12782020 | pubmed:affiliation | Department of Cardiology and the Cardiovascular Research Laboratory, Tel-Aviv Medical Center, Tel-Aviv, Israel. jacobg@post.tau.ac.il | lld:pubmed |
pubmed-article:12782020 | pubmed:publicationType | Journal Article | lld:pubmed |