| pubmed-article:12773531 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0664613 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C1332098 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:12773531 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:12773531 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:12773531 | pubmed:dateCreated | 2003-8-4 | lld:pubmed |
| pubmed-article:12773531 | pubmed:abstractText | Induction and execution of apoptosis programs are generally believed to be mediated through a hierarchy of caspase activation. By using two cellular variants obtained from the L1210 cell line (L1210/S and L1210/0), we have shown previously that staurosporine induces apoptotic cell death through both caspase-dependent and caspase-independent pathways. Both pathways normally coexisted in L1210/S cells, whereas L1210/0 cells lacked the ability to activate caspases despite the confirmed presence of both procaspase-3 and -9. Here we show that this defect in caspase activation is not due to mechanisms such as an absence of cytochrome c release, the expression of non-functional caspases, or the presence of an endogenous inhibitor but results from the loss of apoptosis protease activator protein-1 (APAF-1) expression. This absence of APAF-1 protein results from multiple alterations at both genomic and transcriptional levels. However, although this lack of APAF-1 delays the apoptotic program, it does not hamper its execution. Importantly, in these cells, apoptosis develops not only in an APAF-1-independent way but also in the absence of caspase-3 and -9 activation. Altogether these findings provide evidence that apoptosis may occur through alternative signaling pathways independent of APAF-1 expression and totally dissociated from any caspase processing. Therefore, the L1210/0 variant sub-line provides a valuable tool for the elucidation of these pathways. | lld:pubmed |
| pubmed-article:12773531 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12773531 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12773531 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12773531 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12773531 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12773531 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:FlexorMariaM | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:LanotteMichel... | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:Ségal-Bendird... | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:HillionJosett... | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:BelmokhtarCha... | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:FiorentinoSus... | lld:pubmed |
| pubmed-article:12773531 | pubmed:author | pubmed-author:DudognonCharl... | lld:pubmed |
| pubmed-article:12773531 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12773531 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:12773531 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12773531 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12773531 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12773531 | pubmed:pagination | 29571-80 | lld:pubmed |
| pubmed-article:12773531 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12773531 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12773531 | pubmed:articleTitle | Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes. | lld:pubmed |
| pubmed-article:12773531 | pubmed:affiliation | INSERM U496, Centre G. Hayem, Hôpital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris, France. | lld:pubmed |
| pubmed-article:12773531 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12773531 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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