| pubmed-article:12771418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12771418 | lifeskim:mentions | umls-concept:C1005556 | lld:lifeskim |
| pubmed-article:12771418 | lifeskim:mentions | umls-concept:C1325725 | lld:lifeskim |
| pubmed-article:12771418 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:12771418 | lifeskim:mentions | umls-concept:C0185027 | lld:lifeskim |
| pubmed-article:12771418 | pubmed:issue | Pt 6 | lld:pubmed |
| pubmed-article:12771418 | pubmed:dateCreated | 2003-5-28 | lld:pubmed |
| pubmed-article:12771418 | pubmed:abstractText | The epitope for a human papillomavirus (HPV) type 6 conformation-dependent, neutralizing monoclonal antibody (mAb) was partially mapped using HPV L1 recombinant virus-like particles (VLPs). The mAb H6.J54 is cross-reactive with the closely related HPV types 6 and 11. By making HPV-6-like amino acid substitutions in the cottontail rabbit papillomavirus (CRPV) major capsid protein L1, we were able to transfer H6.J54 binding activity into a CRPV/HPV-6 hybrid L1 protein. Full binding activity was achieved with only nine amino acid changes and identified a region centred on the HPV-6 residues 49-54. This region has previously been shown to be a critical part of HPV-6 type-specific epitopes. Fine mapping of the region by scanning a series of alanine substitution mutations showed that in HPV-6 VLPs this type-common epitope overlaps HPV-6 type-specific epitopes. | lld:pubmed |
| pubmed-article:12771418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12771418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771418 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12771418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12771418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12771418 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12771418 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:LudmererSteve... | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:CookJames CJC | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:JansenKathrin... | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:ChristensenNe... | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:WangXin-MinXM | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:McClementsWil... | lld:pubmed |
| pubmed-article:12771418 | pubmed:author | pubmed-author:LeeJessica... | lld:pubmed |
| pubmed-article:12771418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12771418 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:12771418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12771418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12771418 | pubmed:pagination | 1493-7 | lld:pubmed |
| pubmed-article:12771418 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:meshHeading | pubmed-meshheading:12771418... | lld:pubmed |
| pubmed-article:12771418 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12771418 | pubmed:articleTitle | Human papillomavirus type 6 virus-like particles present overlapping yet distinct conformational epitopes. | lld:pubmed |
| pubmed-article:12771418 | pubmed:affiliation | Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. | lld:pubmed |
| pubmed-article:12771418 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12771418 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12771418 | lld:pubmed |
