| pubmed-article:12767900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12767900 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:12767900 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12767900 | pubmed:dateCreated | 2003-5-27 | lld:pubmed |
| pubmed-article:12767900 | pubmed:abstractText | We previously reported synergistic induction of apoptosis by IFN-gamma plus either cyclosporin A (CsA) or tacrolimus (FK506) in gastric carcinoma cells. In this study, we aimed to elucidate the mechanism for this synergistic induction of apoptosis. IFN-gamma plus CsA synergistically induced caspase-3 mediated apoptosis in gastric carcinoma cells. Although IFN-gamma induced activation of signal transducer and activator of transcription1 (STAT1) and expression of interferon regulatory factor-1 (IRF-1) mRNA, IFN-gamma alone was not able to induce caspase-3 activation and apoptosis. When gastric carcinoma cells were treated with cyclohexamide, a protein synthesis inhibitor, following IFN-gamma pretreatment, caspase-3 was activated, and apoptosis was markedly induced. These findings suggest the existence of IFN-gamma-induced anti-apoptotic pathway and we evaluated the effect of IFN-gamma and CsA on calcium-sensitive nuclear factor-kappa B (NF-kappa B) activation. IFN-gamma increased intracellular calcium ion concentration ([Ca(2+)](i)) consisting of a spike and a sustained phase, and the latter was completely abrogated by CsA. Activation of NF-kappa B occurred in response to IFN-gamma, and which was markedly inhibited by either CsA or FK506. NF-kappa B decoy also enhanced the cytotoxic effect of IFN-gamma. These results suggest that IFN-gamma may simultaneously induce the STAT1-mediated apoptotic pathway and the anti-apoptotic pathway through calcium-activated NF-kappa B and that inhibition of the latter by CsA may result in dominance of the apoptosis-inducing pathway. | lld:pubmed |
| pubmed-article:12767900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12767900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12767900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12767900 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12767900 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:TanakaMasaoM | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:IharaEikichiE | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:KatanoMitsuoM | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:MorisakiTakas... | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:UchiyamaAkihi... | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:KanaideHideoH | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:HiranoKatsuya... | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:MatsunagaHisa... | lld:pubmed |
| pubmed-article:12767900 | pubmed:author | pubmed-author:BeppuKiichiro... | lld:pubmed |
| pubmed-article:12767900 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12767900 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:12767900 | pubmed:volume | 305 | lld:pubmed |
| pubmed-article:12767900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12767900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12767900 | pubmed:pagination | 797-805 | lld:pubmed |
| pubmed-article:12767900 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12767900 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12767900 | pubmed:articleTitle | Inhibition of interferon-gamma-activated nuclear factor-kappa B by cyclosporin A: A possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells. | lld:pubmed |
| pubmed-article:12767900 | pubmed:affiliation | Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyusyu University, Fukuoka 812-8582, Japan. | lld:pubmed |
| pubmed-article:12767900 | pubmed:publicationType | Journal Article | lld:pubmed |
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