| pubmed-article:12760965 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12760965 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:12760965 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:12760965 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:12760965 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12760965 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12760965 | pubmed:dateCreated | 2003-5-22 | lld:pubmed |
| pubmed-article:12760965 | pubmed:abstractText | Extensive tracheal defects may pose a life-threatening dilemma. Although tracheal transplantation may represent a reconstructive solution, very little is known regarding the immunobiology and behavior of tracheal allografts. The objective of this study was to assess the pattern and kinetics of re-epithelialization of orthotopic tracheal allografts in immunosuppressed recipients. Thirty-eight age-matched mice were randomly assigned to five experimental groups. BALB/c donor tracheal segments were orthotopically transplanted into either syngeneic BALB/c or MHC mismatched allogeneic C57BL/6 recipients with and without immunosuppression. On post-transplant days 7, 14, 28, 48, and 62, animals from each group were evaluated by serial histology, electron microscopy, and serial immunohistochemical analysis for mucosal phenotype, re-epithelialization pattern, and lymphocyte subpopulations. Nonimmunosuppressed recipients underwent recipient-derived basal cell re-epithelialization by Day 48, with differentiation into a sparse population of ciliated columnar epithelium by Day 62, whereas immunosuppressed recipients underwent basal cell re-epithelialization 28 d after transplantation and differentiation into a dense population of ciliated columnar epithelium by Day 48. The re-epithelialization process occurred in a definable pattern that was significantly enhanced with the addition of immunosuppression. Orthotopic tracheal transplants undergo progressive re-epithelialization with recipient-derived basal cells that differentiate into ciliated columnar epithelium in a definable pattern that is enhanced with the addition of immunosuppression. | lld:pubmed |
| pubmed-article:12760965 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12760965 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12760965 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12760965 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12760965 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12760965 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12760965 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:12760965 | pubmed:author | pubmed-author:BrombergJonat... | lld:pubmed |
| pubmed-article:12760965 | pubmed:author | pubmed-author:GendenEric... | lld:pubmed |
| pubmed-article:12760965 | pubmed:author | pubmed-author:MayerLloydL | lld:pubmed |
| pubmed-article:12760965 | pubmed:author | pubmed-author:IskanderAndre... | lld:pubmed |
| pubmed-article:12760965 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12760965 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:12760965 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12760965 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12760965 | pubmed:pagination | 673-81 | lld:pubmed |
| pubmed-article:12760965 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:meshHeading | pubmed-meshheading:12760965... | lld:pubmed |
| pubmed-article:12760965 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12760965 | pubmed:articleTitle | The kinetics and pattern of tracheal allograft re-epithelialization. | lld:pubmed |
| pubmed-article:12760965 | pubmed:affiliation | Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. eric.genden@mssm.edu | lld:pubmed |
| pubmed-article:12760965 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12760965 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12760965 | lld:pubmed |
