| pubmed-article:12757396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C2700384 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0012935 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:12757396 | lifeskim:mentions | umls-concept:C0070276 | lld:lifeskim |
| pubmed-article:12757396 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12757396 | pubmed:dateCreated | 2003-5-21 | lld:pubmed |
| pubmed-article:12757396 | pubmed:abstractText | Synthesis of 3'-3'-linked oligonucleotides branched by a pentaerythritol linker is described. The branched oligonucleotides were synthesized on a DNA/RNA synthesizer using a controlled pore glass (CPG) with a pentaerythritol linker carrying 4,4'-dimethoxytrityl (DMTr) and levulinyl (Lev) groups. The stability of the triplexes between the branched oligonucleotides and the target single-stranded DNA or RNA was studied by thermal denaturation. The oligonucleotides with the pentaerythritol linker formed thermally stable triplexes with the single-stranded DNA and RNA. Furthermore, the branched oligonucleotides containing 2'-O-methylribonucleosides, especially the oligonucleotide composed of 2'-deoxyribonucleosides and 2'-O-methylribonucleosides, stabilized the triplexes with the single-stranded DNA or RNA. Thus, the branched oligonucleotide containing 2'-O-methylribonucleosides may be a candidate for a novel antisense molecule by the triplex formation. | lld:pubmed |
| pubmed-article:12757396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12757396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12757396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12757396 | pubmed:issn | 1043-1802 | lld:pubmed |
| pubmed-article:12757396 | pubmed:author | pubmed-author:UenoYoshihito... | lld:pubmed |
| pubmed-article:12757396 | pubmed:author | pubmed-author:MatsudaAkiraA | lld:pubmed |
| pubmed-article:12757396 | pubmed:author | pubmed-author:KitadeYukioY | lld:pubmed |
| pubmed-article:12757396 | pubmed:author | pubmed-author:ShibataAyaA | lld:pubmed |
| pubmed-article:12757396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12757396 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:12757396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12757396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12757396 | pubmed:pagination | 684-9 | lld:pubmed |
| pubmed-article:12757396 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:meshHeading | pubmed-meshheading:12757396... | lld:pubmed |
| pubmed-article:12757396 | pubmed:articleTitle | Synthesis of 3'-3'-linked oligonucleotides branched by a pentaerythritol linker and the thermal stabilities of the triplexes with single-stranded DNA or RNA. | lld:pubmed |
| pubmed-article:12757396 | pubmed:affiliation | Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan. | lld:pubmed |
| pubmed-article:12757396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12757396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
