| pubmed-article:12756298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C1517162 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:12756298 | lifeskim:mentions | umls-concept:C0205615 | lld:lifeskim |
| pubmed-article:12756298 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12756298 | pubmed:dateCreated | 2003-6-11 | lld:pubmed |
| pubmed-article:12756298 | pubmed:abstractText | Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for transplantation. Activation of insulin expression, storage, and regulated secretion in stem/progenitor cells offers novel ways to overcome this shortage. We explored whether fetal human progenitor liver cells (FH) could be induced to differentiate into insulin-producing cells after expression of the pancreatic duodenal homeobox 1 (Pdx1) gene, which is a key regulator of pancreatic development and insulin expression in beta cells. FH cells possess a considerable replication capacity, and this was further extended by introduction of the gene for the catalytic subunit of human telomerase. Immortalized FH cells expressing Pdx1 activated multiple beta-cell genes, produced and stored considerable amounts of insulin, and released insulin in a regulated manner in response to glucose. When transplanted into hyperglycemic immunodeficient mice, the cells restored and maintained euglycemia for prolonged periods. Quantitation of human C-peptide in the mouse serum confirmed that the glycemia was normalized by the transplanted human cells. This approach offers the potential of a novel source of cells for transplantation into patients with type 1 diabetes. | lld:pubmed |
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| pubmed-article:12756298 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12756298 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12756298 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12756298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12756298 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12756298 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:GuptaSanjeevS | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:SappalBaljit... | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:ZernMark AMA | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:EfratShimonS | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:GiriRanjit... | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:ZalzmanMichal... | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:BerkovichIrin... | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:KarnieliOhadO | lld:pubmed |
| pubmed-article:12756298 | pubmed:author | pubmed-author:FleischerNorm... | lld:pubmed |
| pubmed-article:12756298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12756298 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:12756298 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12756298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12756298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12756298 | pubmed:pagination | 7253-8 | lld:pubmed |
| pubmed-article:12756298 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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