| pubmed-article:12750407 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1135629 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1417530 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:12750407 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:12750407 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12750407 | pubmed:dateCreated | 2003-5-16 | lld:pubmed |
| pubmed-article:12750407 | pubmed:abstractText | The Toll-like receptors (TLRs) are recently discovered germline-encoded receptors on APCs that are critically important in innate immune recognition of microbial pathogens. However, their role in solid-organ transplantation is unknown. To explore this role, we employed a skin allograft model using mice with targeted deletion of the universal TLR signal adaptor protein, MyD88. We report that minor antigen-mismatched (HY-mismatched) allograft rejection cannot occur in the absence of MyD88 signaling. Furthermore, we show that the inability to reject these allografts results from a reduced number of mature DCs in draining lymph nodes, leading to impaired generation of anti-graft-reactive T cells and impaired Th1 immunity. Hence, this work demonstrates that TLRs can be activated in a transplant setting and not solely by infections. These results link innate immunity to the initiation of the adaptive alloimmune response. | lld:pubmed |
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| pubmed-article:12750407 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12750407 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12750407 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12750407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12750407 | pubmed:month | May | lld:pubmed |
| pubmed-article:12750407 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12750407 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:12750407 | pubmed:author | pubmed-author:LakkisFadi... | lld:pubmed |
| pubmed-article:12750407 | pubmed:author | pubmed-author:GoldsteinDani... | lld:pubmed |
| pubmed-article:12750407 | pubmed:author | pubmed-author:TesarBethany... | lld:pubmed |
| pubmed-article:12750407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12750407 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:12750407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12750407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12750407 | pubmed:pagination | 1571-8 | lld:pubmed |
| pubmed-article:12750407 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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