| pubmed-article:12749900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C0074825 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C2698650 | lld:lifeskim |
| pubmed-article:12749900 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:12749900 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12749900 | pubmed:dateCreated | 2003-5-16 | lld:pubmed |
| pubmed-article:12749900 | pubmed:abstractText | A series of 1-benzoyl isoquinolines, based on compound 1, was synthesized and evaluated for their ability to displace IGF-I from its complex with IGF-binding protein-3. Successful modifications of 1 included the replacement of the 3,4-dihydroxybenzoyl group with a substituted benzyl group. These alternations culminated in the discovery of compounds such as 7o which had excellent in vitro potency (K(i)=9.4 nM) but with one less of the labile catechol functionality of 1. | lld:pubmed |
| pubmed-article:12749900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12749900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749900 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12749900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12749900 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12749900 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:YewP RPR | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:ZhuYun-FeiYF | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:WilcoxenKeith... | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:LingNicholasN | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:McCarthyJames... | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:HuangCharles... | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:GrossTimothyT | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:ConnorsPatric... | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:StrackNathali... | lld:pubmed |
| pubmed-article:12749900 | pubmed:author | pubmed-author:GrossRaymondR | lld:pubmed |
| pubmed-article:12749900 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12749900 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:12749900 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12749900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12749900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12749900 | pubmed:pagination | 1927-30 | lld:pubmed |
| pubmed-article:12749900 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:meshHeading | pubmed-meshheading:12749900... | lld:pubmed |
| pubmed-article:12749900 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12749900 | pubmed:articleTitle | 6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain. | lld:pubmed |
| pubmed-article:12749900 | pubmed:affiliation | Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 10555 Science Center Drive, San Diego, CA 92121, USA. | lld:pubmed |
| pubmed-article:12749900 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12749900 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12749900 | lld:pubmed |
