| pubmed-article:12749828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12749828 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:12749828 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:12749828 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12749828 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:12749828 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12749828 | pubmed:dateCreated | 2003-5-16 | lld:pubmed |
| pubmed-article:12749828 | pubmed:abstractText | Sensory neuropeptides have been proposed to play a key role in the pathogenesis of a number of respiratory diseases such as asthma, chronic obstructive pulmonary disease or chronic cough. Next to prominent neuropeptides such as tachykinins or vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) has long been suggested to participate in airway physiology and pathophysiology. CGRP is a 37 amino-acid peptide which is expressed by nerve fibers projecting to the airways and by pulmonary neuroendocrine cells. The most prominent effects of CGRP in the airways are vasodilatation and in a few instances bronchoconstriction. A further pulmonary effect of CGRP is the induction of eosinophil migration and the stimulation of beta-integrin-mediated T cell adhesion to fibronectin at the site of inflammation. By contrast, CGRP inhibits macrophage secretion and the capacity of macrophages to activate T-cells, indicating a potential anti-inflammatory effect. Due to the complex pulmonary effects of CGRP with bronchoconstriction and vasodilatation and diverse immunomodulatory actions, potential anti-asthma drugs based on this peptide have not been established so far. However, targeting the effects of CGRP may be of value for future strategies in nerve modulation. | lld:pubmed |
| pubmed-article:12749828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12749828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12749828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12749828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12749828 | pubmed:issn | 1094-5539 | lld:pubmed |
| pubmed-article:12749828 | pubmed:author | pubmed-author:SpringerJoche... | lld:pubmed |
| pubmed-article:12749828 | pubmed:author | pubmed-author:GronebergDavi... | lld:pubmed |
| pubmed-article:12749828 | pubmed:author | pubmed-author:FischerAxelA | lld:pubmed |
| pubmed-article:12749828 | pubmed:author | pubmed-author:GeppettiPiera... | lld:pubmed |
| pubmed-article:12749828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12749828 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:12749828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12749828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12749828 | pubmed:pagination | 121-30 | lld:pubmed |
| pubmed-article:12749828 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:meshHeading | pubmed-meshheading:12749828... | lld:pubmed |
| pubmed-article:12749828 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12749828 | pubmed:articleTitle | Calcitonin gene-related peptide as inflammatory mediator. | lld:pubmed |
| pubmed-article:12749828 | pubmed:affiliation | Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Campus-Virchow, Humboldt-University Berlin, 13353 Berlin, Germany. | lld:pubmed |
| pubmed-article:12749828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12749828 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:12749828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12749828 | lld:pubmed |
