| pubmed-article:12745412 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C0003431 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C0027912 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C0457801 | lld:lifeskim |
| pubmed-article:12745412 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:12745412 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12745412 | pubmed:dateCreated | 2003-5-14 | lld:pubmed |
| pubmed-article:12745412 | pubmed:abstractText | The function of the central alpha-adrenergic, serotoninergic and dopaminergic systems was investigated in 30 heroin-dependent subjects, 6 - 8 weeks after detoxification and in 22 psychophysically healthy controls (group C). Twelve heroin-dependent subjects with antisocial personality disorder (ASPD) (group A), 18 heroin-dependent subjects without other Axis I and II pathologies (group B) were included among abstinent substance abusers. The norepinephrine (NE) function was evaluated by the GH responses to acute stimulation with clonidine (clon); the serotonin (5-HT) function by the PRL and cortisol (CORT) responses to acute stimulation with d-fenfluramine (d-fen) and the dopamine (DA) function was investigated by growth hormone (GH) and prolactin (PRL) responses to acute administration of bromocriptine (brom). Alpha-adrenergic sensitivity, as measured by the GH-clon test, was found significantly reduced in A subjects (ASPD), in comparison with B subjects and controls. PRL and CORT responses to d-fen were significantly blunted both in A and B subjects, in comparison with control subjects. DA receptors sensitivity seems to be reduced significantly in ASPD (A subjects); in contrast, heroin addicts without open psychiatric co-morbidity showed unimpaired responses to brom challenge; a significantly lower GH response to brom and a lack of PRL suppression in ASPD subjects could express D2 postsynaptic receptor hyposensitivity possibly related to DA gene variants associated to co-morbid disorder. In sum, the study of central monoamine function revealed an alteration of the 5-HT system in all detoxified heroin-dependent subjects. A significant reduction of alpha-adrenergic receptors sensitivity and the hyposensitivity of postsynaptic DA receptors in ASPD subjects suggest once again that specific biological correlates of psychiatric co-morbidity may characterize substance abusers subtypes. | lld:pubmed |
| pubmed-article:12745412 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12745412 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12745412 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12745412 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12745412 | pubmed:issn | 1355-6215 | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:BrambillaFF | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:DelsignoreRR | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:MoyWW | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:CaccavariRR | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:GerraGG | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:ZaimovicAA | lld:pubmed |
| pubmed-article:12745412 | pubmed:author | pubmed-author:BussandriMM | lld:pubmed |
| pubmed-article:12745412 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12745412 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:12745412 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12745412 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12745412 | pubmed:pagination | 23-32 | lld:pubmed |
| pubmed-article:12745412 | pubmed:dateRevised | 2007-3-27 | lld:pubmed |
| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
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| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
| pubmed-article:12745412 | pubmed:meshHeading | pubmed-meshheading:12745412... | lld:pubmed |
| pubmed-article:12745412 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12745412 | pubmed:articleTitle | Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. | lld:pubmed |
| pubmed-article:12745412 | pubmed:affiliation | Centro Studi Farmaco-tossicopendenze, Ser T, Ausl, Parma, Italy. ggerra@ausl.pr.it | lld:pubmed |
| pubmed-article:12745412 | pubmed:publicationType | Journal Article | lld:pubmed |
