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pubmed-article:12744848pubmed:abstractTextWe report on the findings of an exploratory review of evidence published in English from 1945 to identify the best post-exposure prophylaxis treatment and the longest acceptable interval after exposure for prophylaxis to be effective. We found no evidence that post-exposure administration of currently available immunoglobulins is effective in preventing hepatitis A infection and disease. The use of immunoglobulins for immunoprophylaxis should not be widely recommended until a systematic review of the evidence has been conducted. We recommend that active immunization to secondary contacts of exposed and vaccinated subjects be offered.lld:pubmed
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pubmed-article:12744848pubmed:authorpubmed-author:TalianiGloria...lld:pubmed
pubmed-article:12744848pubmed:authorpubmed-author:GaetaGiovanni...lld:pubmed
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pubmed-article:12744848pubmed:pagination2234-7lld:pubmed
pubmed-article:12744848pubmed:dateRevised2005-11-16lld:pubmed
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pubmed-article:12744848pubmed:year2003lld:pubmed
pubmed-article:12744848pubmed:articleTitleHepatitis A: post-exposure prophylaxis.lld:pubmed
pubmed-article:12744848pubmed:affiliationClinica delle Malattie Infettive, Università di Firenze, Viale Morgagni 85, 50134 Firenze, Italy. talianig@ao-careggi.toscana.itlld:pubmed
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