| pubmed-article:12740431 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12740431 | lifeskim:mentions | umls-concept:C0600466 | lld:lifeskim |
| pubmed-article:12740431 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12740431 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:12740431 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12740431 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12740431 | pubmed:dateCreated | 2003-5-28 | lld:pubmed |
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| pubmed-article:12740431 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12740431 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12740431 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12740431 | pubmed:abstractText | Xenotransplantation of porcine tissues has the potential to treat a wide variety of major health problems including organ failure and diabetes. Balanced against the potential benefits of xenotransplantation, however, is the risk of human infection with a porcine microorganism. In particular, the transmission of porcine endogenous retrovirus (PERV) is a major concern [Chapman, L. E. & Bloom, E. T. (2001) J. Am. Med. Assoc. 285, 2304-2306]. Here we report the identification of two, sequence-related, human proteins that act as receptors for PERV-A, encoded by genes located on chromosomes 8 and 17. We also describe homologs from baboon and porcine cells that also are active as receptors. Conversely, activity could not be demonstrated with a syntenic murine receptor homolog. Sequence analysis indicates that PERV-A receptors [human PERV-A receptor (HuPAR)-1, HuPAR-2, baboon PERV-A receptor 2, and porcine PERV-A receptor] are multiple membrane-spanning proteins similar to receptors for other gammaretroviruses. Expression is widespread in human tissues including peripheral blood mononuclear cells, but their biological functions are unknown. The identification of the PERV-A receptors opens avenues of research necessary for a more complete assessment of the retroviral risks of pig to human xenotransplantation. | lld:pubmed |
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| pubmed-article:12740431 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12740431 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12740431 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12740431 | pubmed:month | May | lld:pubmed |
| pubmed-article:12740431 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:TakeuchiYasuh... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:MiyazawaTakay... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:OldmixonBeth... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:WoodJames CJC | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:EricssonThoma... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:PatienceClive... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:KitagawaYoshi... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:WeissRobin... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:SalomonDaniel... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:QuinnGaryG | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:TemplinChrist... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:FarhadianShel... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:SulingKristen... | lld:pubmed |
| pubmed-article:12740431 | pubmed:author | pubmed-author:IshiiJennifer... | lld:pubmed |
| pubmed-article:12740431 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12740431 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:12740431 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12740431 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12740431 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12740431 | pubmed:pagination | 6759-64 | lld:pubmed |
| pubmed-article:12740431 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12740431 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12740431 | pubmed:articleTitle | Identification of receptors for pig endogenous retrovirus. | lld:pubmed |
| pubmed-article:12740431 | pubmed:affiliation | Immerge BioTherapeutics, Inc., 300 Technology Square, Cambridge, MA 02139, USA. | lld:pubmed |
| pubmed-article:12740431 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12740431 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12740431 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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