| pubmed-article:12719269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12719269 | lifeskim:mentions | umls-concept:C1518565 | lld:lifeskim |
| pubmed-article:12719269 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:12719269 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:12719269 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:12719269 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12719269 | pubmed:dateCreated | 2003-4-29 | lld:pubmed |
| pubmed-article:12719269 | pubmed:abstractText | The basal conductance of unstimulated frog olfactory receptor neurons was investigated using whole-cell and perforated-patch recording. The input conductance, measured between -80 mV and -60 mV, averaged 0.25 nS in physiological saline. Studies were conducted to determine whether part of the input conductance is due to gating of neuronal cyclic-nucleotide-gated (CNG) channels. In support of this idea, the neuronal resting conductance was reduced by each of five treatments that reduce current through CNG channels: external application of divalent cations or amiloride; treatment with either of two adenylate cyclase inhibitors; and application of AMP-PNP, a competitive substrate for adenylate cyclase. The current blocked by divalent cations or by a cyclase inhibitor reversed near 0 mV, as expected for a CNG current. Under physiological conditions, gating of CNG channels contributes approximately 0.06 nS to the resting neuronal conductance. This implies a resting cAMP concentration of 0.1-0.3 micro M. A theoretical model suggests that a neuron containing 0.1-0.3 micro M cAMP is poised to give the largest possible depolarization in response to a very small olfactory stimulus. Although having CNG channels open at rest decreases the voltage change resulting from a given receptor current, it more substantially increases the receptor current resulting from a given increase in [cAMP]. | lld:pubmed |
| pubmed-article:12719269 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12719269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12719269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12719269 | pubmed:month | May | lld:pubmed |
| pubmed-article:12719269 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:12719269 | pubmed:author | pubmed-author:PunRaymund... | lld:pubmed |
| pubmed-article:12719269 | pubmed:author | pubmed-author:KleeneSteven... | lld:pubmed |
| pubmed-article:12719269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12719269 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:12719269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12719269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12719269 | pubmed:pagination | 3425-35 | lld:pubmed |
| pubmed-article:12719269 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:meshHeading | pubmed-meshheading:12719269... | lld:pubmed |
| pubmed-article:12719269 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12719269 | pubmed:articleTitle | Contribution of cyclic-nucleotide-gated channels to the resting conductance of olfactory receptor neurons. | lld:pubmed |
| pubmed-article:12719269 | pubmed:affiliation | Department of Molecular and Cellular Physiology, University of Cincinnati, PO Box 670576, Cincinnati, OH 45267, USA. raymund.pun@uc.edu | lld:pubmed |
| pubmed-article:12719269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12719269 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12719269 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12719269 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| pubmed-article:12719269 | pubmed:publicationType | Validation Studies | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12719269 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12719269 | lld:pubmed |
