| pubmed-article:12717805 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0054201 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C1516801 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0599748 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:12717805 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:12717805 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:12717805 | pubmed:dateCreated | 2003-4-28 | lld:pubmed |
| pubmed-article:12717805 | pubmed:abstractText | A sensitive, rapid and selective liquid chromatography negative electrospray ionization tandem mass spectrometry [LC-(-)ESI-MS-MS] method has been developed and validated for the simultaneous quantification of budesonide (BUD) and its major metabolites, 6beta-hydroxybudesonide (OH-BUD) and 16alpha-hydroxyprednisolone (OH-PRED) in human plasma. The method was validated over a linear range from 0.1 to 10 ng/mL for all three analytes using a solid-phase extraction procedure with 9-fluoro-hydrocortisone as the internal standard. The between-day and within-day coefficients of variation for all compounds were < or =20% at the concentrations of lower limit of quantification and < or =15% at other quality control concentrations. The utility of this assay was demonstrated by monitoring BUD, OH-BUD and OH-PRED plasma concentrations in one healthy subject for 24 h following a 3 mg oral dose of budesonide, administered as a pH modified release capsule (Budenofalk) to healthy volunteers. | lld:pubmed |
| pubmed-article:12717805 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12717805 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717805 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12717805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717805 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12717805 | pubmed:issn | 0269-3879 | lld:pubmed |
| pubmed-article:12717805 | pubmed:author | pubmed-author:MoellmannHH | lld:pubmed |
| pubmed-article:12717805 | pubmed:author | pubmed-author:HochhausGünth... | lld:pubmed |
| pubmed-article:12717805 | pubmed:author | pubmed-author:WangYaningY | lld:pubmed |
| pubmed-article:12717805 | pubmed:author | pubmed-author:TangYufeiY | lld:pubmed |
| pubmed-article:12717805 | pubmed:copyrightInfo | Copyright 2003 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:12717805 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12717805 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:12717805 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12717805 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12717805 | pubmed:pagination | 158-64 | lld:pubmed |
| pubmed-article:12717805 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:meshHeading | pubmed-meshheading:12717805... | lld:pubmed |
| pubmed-article:12717805 | pubmed:articleTitle | Simultaneous quantification of budesonide and its two metabolites, 6beta-hydroxybudesonide and 16alpha-hydroxyprednisolone, in human plasma by liquid chromatography negative electrospray ionization tandem mass spectrometry. | lld:pubmed |
| pubmed-article:12717805 | pubmed:affiliation | Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA. | lld:pubmed |
| pubmed-article:12717805 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12717805 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
