| pubmed-article:12717423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:12717423 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:12717423 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12717423 | pubmed:dateCreated | 2003-4-28 | lld:pubmed |
| pubmed-article:12717423 | pubmed:abstractText | Bfl-1 is an antiapoptotic Bcl-2 family member and a mouse A1 homologue. The mouse A1 has been reported to have three isoforms, but little is known about human Bfl-1. By reverse-transcriptase polymerase chain reaction analysis, we have identified Bfl-1S (short form), an alternative splice variant of Bfl-1. The Bfl-1S primary sequence contains four conserved Bcl-2 homology (BH) domains and a positive-charged C-terminus containing KKRK amino acids. The expression of Bfl-1S mRNA was detected predominantly in normal lymph nodes and in B-lymphoid leukemia cells. Confocal microscopic analysis using green fluorescence protein fusion proteins demonstrated that Bfl-1S is localized in the nucleus by its C-terminus as an intrinsic nuclear localization sequence. Bfl-1S acts as an antiapoptotic agent in coexpression experiments with Bax, a proapoptotic molecule. The expression of Bfl-1S provided significant resistance against staurosporine (STS) treatments in Molt-4 human T-leukemia cells. Bfl-1S also significantly inhibited the cleavage of Bid, and of caspases 3 and 8 against STS treatment. These results indicate that Bfl-1S is a novel human Bcl-2 family member that possesses antiapoptotic function. | lld:pubmed |
| pubmed-article:12717423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12717423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12717423 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12717423 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:ShimYhong-Hee... | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:LeeSeung-Sook... | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:KimChul-WooCW | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:LeeMin-JungMJ | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:KoJae-KyunJK | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:ChoSun-HeeSH | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:ChoJung-AhJA | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:LeeBo-YoungBY | lld:pubmed |
| pubmed-article:12717423 | pubmed:author | pubmed-author:KohJason... | lld:pubmed |
| pubmed-article:12717423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12717423 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:12717423 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12717423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12717423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12717423 | pubmed:pagination | 2457-65 | lld:pubmed |
| pubmed-article:12717423 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:meshHeading | pubmed-meshheading:12717423... | lld:pubmed |
| pubmed-article:12717423 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12717423 | pubmed:articleTitle | Bfl-1S, a novel alternative splice variant of Bfl-1, localizes in the nucleus via its C-terminus and prevents cell death. | lld:pubmed |
| pubmed-article:12717423 | pubmed:affiliation | Department of Pathology, Tumor Immunity Medical Research Center and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. | lld:pubmed |
| pubmed-article:12717423 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12717423 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12717423 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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