| pubmed-article:12714745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12714745 | lifeskim:mentions | umls-concept:C2700455 | lld:lifeskim |
| pubmed-article:12714745 | lifeskim:mentions | umls-concept:C0285890 | lld:lifeskim |
| pubmed-article:12714745 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:12714745 | lifeskim:mentions | umls-concept:C1947974 | lld:lifeskim |
| pubmed-article:12714745 | lifeskim:mentions | umls-concept:C1720655 | lld:lifeskim |
| pubmed-article:12714745 | pubmed:issue | 5619 | lld:pubmed |
| pubmed-article:12714745 | pubmed:dateCreated | 2003-4-25 | lld:pubmed |
| pubmed-article:12714745 | pubmed:abstractText | Alpha-synuclein (alpha-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that alpha-syn induces fibrillization of tau and that coincubation of tau and alpha-syn synergistically promotes fibrillization of both proteins. The in vivo relevance of these findings is grounded in the co-occurrence of alpha-syn and tau filamentous amyloid inclusions in humans, in single transgenic mice that express A53T human alpha-syn in neurons, and in oligodendrocytes of bigenic mice that express wild-type human alpha-syn plus P301L mutant tau. This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases. | lld:pubmed |
| pubmed-article:12714745 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12714745 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12714745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12714745 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12714745 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:LeeVirginia... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:TrojanowskiJo... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:HiguchiMakoto... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:GolbeLawrence... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:FormanMark... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:GiassonBenoit... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:GravesCharles... | lld:pubmed |
| pubmed-article:12714745 | pubmed:author | pubmed-author:KotzbauerPaul... | lld:pubmed |
| pubmed-article:12714745 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12714745 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:12714745 | pubmed:volume | 300 | lld:pubmed |
| pubmed-article:12714745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12714745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12714745 | pubmed:pagination | 636-40 | lld:pubmed |
| pubmed-article:12714745 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:12714745 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12714745 | pubmed:articleTitle | Initiation and synergistic fibrillization of tau and alpha-synuclein. | lld:pubmed |
| pubmed-article:12714745 | pubmed:affiliation | Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine. | lld:pubmed |
| pubmed-article:12714745 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12714745 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12714745 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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