| pubmed-article:12706680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0007082 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:12706680 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:12706680 | pubmed:issue | 17-18 | lld:pubmed |
| pubmed-article:12706680 | pubmed:dateCreated | 2003-4-22 | lld:pubmed |
| pubmed-article:12706680 | pubmed:abstractText | A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(DL-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. Boosting with a plasmid encoding murine GM-CSF increased the vaccine's efficacy leading to a complete rejection of tumor cells in 50% of mice. This effect was due to activation of MHC class I-restricted CD8(+) T cells coupled with an increased secretion of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-2. Also, specific activation of dendritic cells was indicated by a two-three-fold upregulation of their costimulatory CD80 and MHC class II molecules. This approach may be a promising new strategy for the rational design of cancer vaccines for future clinical applications. | lld:pubmed |
| pubmed-article:12706680 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706680 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12706680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706680 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12706680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12706680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12706680 | pubmed:month | May | lld:pubmed |
| pubmed-article:12706680 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:ZhouHeH | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:SinghManmohan... | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:XiangRongR | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:ReisfeldRalph... | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:O'HaganDerekD | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:UlmerJeffreyJ | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:LuoYunpingY | lld:pubmed |
| pubmed-article:12706680 | pubmed:author | pubmed-author:James... | lld:pubmed |
| pubmed-article:12706680 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12706680 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:12706680 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:12706680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12706680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12706680 | pubmed:pagination | 1938-47 | lld:pubmed |
| pubmed-article:12706680 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:meshHeading | pubmed-meshheading:12706680... | lld:pubmed |
| pubmed-article:12706680 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12706680 | pubmed:articleTitle | Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice. | lld:pubmed |
| pubmed-article:12706680 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, IMM13, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:12706680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12706680 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12706680 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12706680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12706680 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12706680 | lld:pubmed |
