| pubmed-article:12697737 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C1314972 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0019061 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0019134 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0009511 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0056207 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0237497 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C0185023 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C1947904 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C1999228 | lld:lifeskim |
| pubmed-article:12697737 | lifeskim:mentions | umls-concept:C2825781 | lld:lifeskim |
| pubmed-article:12697737 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12697737 | pubmed:dateCreated | 2003-4-16 | lld:pubmed |
| pubmed-article:12697737 | pubmed:abstractText | Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Recent studies have identified a factor H-associated form of HUS, caused by gene mutations that cluster in the C-terminal region of the complement regulator factor H. Here we report how three mutations (E1172Stop, R1210C, and R1215G; each of the latter two identified in three independent cases from different, unrelated families) affect protein function. All three mutations cause reduced binding to the central complement component C3b/C3d to heparin, as well as to endothelial cells. These defective features of the mutant factor H proteins explain progression of endothelial cell and microvascular damage in factor H-associated genetic HUS and indicate a protective role of factor H for tissue integrity during thrombus formation. | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12697737 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12697737 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12697737 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12697737 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:ZipfelPeter... | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:RemuzziGiusep... | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:NeumannHartmu... | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:HellwageJensJ | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:MeriSeppoS | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:NorisMarinaM | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:CaprioliJessi... | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:ManuelianTama... | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:HeinenStefanS | lld:pubmed |
| pubmed-article:12697737 | pubmed:author | pubmed-author:JozsiMihalyM | lld:pubmed |
| pubmed-article:12697737 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12697737 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:12697737 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12697737 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12697737 | pubmed:pagination | 1181-90 | lld:pubmed |
| pubmed-article:12697737 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:meshHeading | pubmed-meshheading:12697737... | lld:pubmed |
| pubmed-article:12697737 | pubmed:year | 2003 | lld:pubmed |
