Linked Life Data

12697296

Source:http://linkedlifedata.com/resource/pubmed/id/12697296

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pubmed-article:12697296pubmed:abstractTextThe neuropeptide orexin-A modulates the sleep-wake cycle such that central administration to rats increases arousal, reduces slow-wave-sleep (SWS) and paradoxical sleep (PS) and delays PS onset. The contribution of orexin-1 and -2 receptor (OXR) activation to this orexin-A response is still unknown. Using the OX(1)R antagonist SB-334867-A we investigated the role of this receptor in orexin-A-induced PS alteration. Male rats prepared for frontal-occipital electroencephalograph, nuchal muscle electromyograph recording and lateral ventricle cannulae received vehicle or orexin-A (10 microg icv) at lights on in combination with vehicle or SB-334867-A (10 or 30 mg/kg ip) 30 min pre-icv injection. The amount of arousal, SWS 1, SWS 2 and PS was determined during the 1st h post icv administration along with the latency to onset of the first> or =10 s epoch of PS. Orexin-A administration reduced the amount and increased the latency to onset of PS. SB-334867-A reversed this effect of orexin-A. The present study demonstrates that the OX(1)R also has a role in orexinergic sleep modulation.lld:pubmed
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pubmed-article:12697296pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12697296pubmed:articleTitleEvidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.lld:pubmed
pubmed-article:12697296pubmed:affiliationNeurology-CEDD, GlaxoSmithkline, New Frontiers Science Park North, Third Avenue, Harlow, Essex, UK, CM19 5AW. martin_i_smith@gsk.comlld:pubmed
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