| pubmed-article:12692541 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12692541 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12692541 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:12692541 | lifeskim:mentions | umls-concept:C2720306 | lld:lifeskim |
| pubmed-article:12692541 | lifeskim:mentions | umls-concept:C1866980 | lld:lifeskim |
| pubmed-article:12692541 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12692541 | pubmed:dateCreated | 2003-5-1 | lld:pubmed |
| pubmed-article:12692541 | pubmed:abstractText | Infectious diseases have influenced population genetics and the evolution of the structure of the human genome in part by selecting for host susceptibility alleles that modify pathogenesis. Norovirus infection is associated with approximately 90% of epidemic non-bacterial acute gastroenteritis worldwide. Here, we show that resistance to Norwalk virus infection is multifactorial. Using a human challenge model, we showed that 29% of our study population was homozygous recessive for the alpha(1,2)fucosyltransferase gene (FUT2) in the ABH histo-blood group family and did not express the H type-1 oligosaccharide ligand required for Norwalk virus binding. The FUT2 susceptibility allele was fully penetrant against Norwalk virus infection as none of these individuals developed an infection after challenge, regardless of dose. Of the susceptible population that encoded a functional FUT2 gene, a portion was resistant to infection, suggesting that a memory immune response or some other unidentified factor also affords protection from Norwalk virus infection. | lld:pubmed |
| pubmed-article:12692541 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12692541 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12692541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692541 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12692541 | pubmed:month | May | lld:pubmed |
| pubmed-article:12692541 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:ChristoffP... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:LindesmithLis... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:JiangXiX | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:StewartPaulP | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:MarionneauSev... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:LindbladLaure... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:RuvoenNathali... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:LePenduJacque... | lld:pubmed |
| pubmed-article:12692541 | pubmed:author | pubmed-author:BaricRalphR | lld:pubmed |
| pubmed-article:12692541 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12692541 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12692541 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12692541 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12692541 | pubmed:pagination | 548-53 | lld:pubmed |
| pubmed-article:12692541 | pubmed:dateRevised | 2008-8-15 | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:meshHeading | pubmed-meshheading:12692541... | lld:pubmed |
| pubmed-article:12692541 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12692541 | pubmed:articleTitle | Human susceptibility and resistance to Norwalk virus infection. | lld:pubmed |
| pubmed-article:12692541 | pubmed:affiliation | Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA. | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:12692541 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2524 | entrezgene:pubmed | pubmed-article:12692541 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12692541 | lld:pubmed |
