| pubmed-article:12692227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C0030358 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C1159909 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:12692227 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12692227 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12692227 | pubmed:dateCreated | 2003-4-14 | lld:pubmed |
| pubmed-article:12692227 | pubmed:abstractText | The papillomavirus life cycle is closely linked to the differentiation program of the host keratinocyte. Thus, late gene expression and viral maturation are restricted to terminally differentiated keratinocytes. A variety of cellular transcription factors including those of the C/EBP family are involved in the regulation of keratinocyte differentiation. In this study we show that the papillomavirus transcription factor E2 cooperates with C/EBPalpha and -beta in transcriptional activation. This synergism was independent of an E2 binding site. E2 and C/EBP factors synergistically transactivated a synthetic promoter construct containing classical C/EBPbeta sites and the C/EBPalpha-responsive proximal promoter of the involucrin gene, which is naturally expressed in differentiating keratinocytes. C/EBPalpha or -beta coprecipitated with E2 proteins derived from human papillomavirus type 8 (HPV8), HPV16, HPV18, and bovine papillomavirus type 1 in vitro and in vivo, indicating complex formation by the cellular and viral factors. The interaction domains could be mapped to the C terminus of E2 and amino acids 261 to 302 located within the bZIP motif of C/EBPbeta. Our data suggest that E2, via its interaction with C/EBP factors, may contribute to enhancing keratinocyte differentiation, which is suppressed by the viral oncoproteins E6 and E7 in HPV-induced lesions. | lld:pubmed |
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| pubmed-article:12692227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12692227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12692227 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12692227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12692227 | pubmed:month | May | lld:pubmed |
| pubmed-article:12692227 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12692227 | pubmed:author | pubmed-author:PfisterHerber... | lld:pubmed |
| pubmed-article:12692227 | pubmed:author | pubmed-author:HadaschikDirk... | lld:pubmed |
| pubmed-article:12692227 | pubmed:author | pubmed-author:HinterkeuserK... | lld:pubmed |
| pubmed-article:12692227 | pubmed:author | pubmed-author:OldakMonikaM | lld:pubmed |
| pubmed-article:12692227 | pubmed:author | pubmed-author:Smola-HessSig... | lld:pubmed |
| pubmed-article:12692227 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12692227 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:12692227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12692227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12692227 | pubmed:pagination | 5253-65 | lld:pubmed |
| pubmed-article:12692227 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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