pubmed-article:12684670 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0004114 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C1513046 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0037028 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C1415102 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C1149300 | lld:lifeskim |
pubmed-article:12684670 | lifeskim:mentions | umls-concept:C0918012 | lld:lifeskim |
pubmed-article:12684670 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:12684670 | pubmed:dateCreated | 2003-4-9 | lld:pubmed |
pubmed-article:12684670 | pubmed:abstractText | Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members. MG-160 is an intrinsic type I cysteine-rich membrane sialoglycoprotein that resides in the medial cisternae of the Golgi apparatus, highly homologous to CFR, chicken fibroblast growth factor receptor, and ESL-1, E-selectin ligand. MG-160 binds fibroblast growth factors (FGFs) and may be involved in the intracellular trafficking of FGFs and the regulation of cellular response to FGFs. In the present study MG-160 expression was evaluated in human brain tumors exhibiting varying degrees of malignancy. At the mRNA level MG-160 expression was inversely correlated with the histological grade of astrocytomas such that high levels of MG-160 were observed in low-grade astrocytomas and low levels in malignant astrocytomas. This differential expression of MG-160 mRNA was verified at the protein level using immunohistochemistry. Grade II astrocytomas displayed consistent and intense staining for MG-160 as seen in normal brain. In contrast to the lower grade tumors, grade IV astrocytomas exhibited variable and weaker expression of MG-160. Our results suggest that, MG-160 may participate in malignant progression in astrocytomas. In addition, other brain tumors and human astrocytoma cell lines were characterized for MG-160 expression. | lld:pubmed |
pubmed-article:12684670 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12684670 | pubmed:language | eng | lld:pubmed |
pubmed-article:12684670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12684670 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12684670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12684670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12684670 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12684670 | pubmed:month | May | lld:pubmed |
pubmed-article:12684670 | pubmed:issn | 1019-6439 | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:TeramotoAkira... | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:TakahashiHiro... | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:SugisakiYuich... | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:GonatasNichol... | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:MorrisonRicha... | lld:pubmed |
pubmed-article:12684670 | pubmed:author | pubmed-author:YamaguchiFumi... | lld:pubmed |
pubmed-article:12684670 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12684670 | pubmed:volume | 22 | lld:pubmed |
pubmed-article:12684670 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12684670 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12684670 | pubmed:pagination | 1045-9 | lld:pubmed |
pubmed-article:12684670 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:12684670 | pubmed:meshHeading | pubmed-meshheading:12684670... | lld:pubmed |
pubmed-article:12684670 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:12684670 | pubmed:articleTitle | Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas. | lld:pubmed |
pubmed-article:12684670 | pubmed:affiliation | Department of Neurosurgery, Nippon Medical School, Tokyo 113-8603, Japan. fyamaguc@nms.ac.jp | lld:pubmed |
pubmed-article:12684670 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12684670 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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