| pubmed-article:12684533 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0007590 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0598175 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C1537562 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0295734 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:12684533 | lifeskim:mentions | umls-concept:C0185027 | lld:lifeskim |
| pubmed-article:12684533 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12684533 | pubmed:dateCreated | 2003-4-16 | lld:pubmed |
| pubmed-article:12684533 | pubmed:abstractText | Emerin and MAN1 are LEM domain-containing integral membrane proteins of the vertebrate nuclear envelope. The function of MAN1 is unknown, whereas emerin is known to interact with nuclear lamins, barrier-to-autointegration factor (BAF), nesprin-1 alpha, and a transcription repressor. Mutations in emerin cause X-linked recessive Emery-Dreifuss muscular dystrophy. Emerin and MAN1 homologs are both conserved in Caenorhabditis elegans, but loss of Ce-emerin has no detectable phenotype. We therefore used C. elegans to test the hypothesis that Ce-MAN1 overlaps functionally with Ce-emerin. Supporting this model, Ce-MAN1 interacted directly with Ce-lamin and Ce-BAF in vitro and required Ce-lamin for its nuclear envelope localization. Interestingly, RNA interference-mediated removal of approximately 90% of Ce-MAN1 was lethal to approximately 15% of embryos. However, in the absence of Ce-emerin, approximately 90% reduction of Ce-MAN1 was lethal to all embryos by the 100-cell stage, with a phenotype involving repeated cycles of anaphase chromosome bridging and cytokinesis ["cell untimely torn" (cut) phenotype]. Immunostaining showed that the anaphase-bridged chromatin specifically retained a mitosis-specific phosphohistone H3 epitope and failed to recruit detectable Ce-lamin or Ce-BAF. These findings show that LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy. | lld:pubmed |
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| pubmed-article:12684533 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12684533 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12684533 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12684533 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12684533 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:LowM BMB | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:GruenbaumYose... | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:LeeKenneth... | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:WilsonKatheri... | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:Segura-Totten... | lld:pubmed |
| pubmed-article:12684533 | pubmed:author | pubmed-author:NeufeldEsterE | lld:pubmed |
| pubmed-article:12684533 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12684533 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12684533 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12684533 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12684533 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12684533 | pubmed:pagination | 4598-603 | lld:pubmed |
| pubmed-article:12684533 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:meshHeading | pubmed-meshheading:12684533... | lld:pubmed |
| pubmed-article:12684533 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12684533 | pubmed:articleTitle | MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:12684533 | pubmed:affiliation | Department of Molecular Biology and Genetics, 439 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA. | lld:pubmed |
| pubmed-article:12684533 | pubmed:publicationType | Journal Article | lld:pubmed |
