| pubmed-article:12675768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0002210 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0494165 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0033706 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0596260 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0950248 | lld:lifeskim |
| pubmed-article:12675768 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:12675768 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12675768 | pubmed:dateCreated | 2003-4-4 | lld:pubmed |
| pubmed-article:12675768 | pubmed:abstractText | We describe the case of an 87-year-old woman who presented to Tokyo Kousei Nenkin Hospital because of appetite loss and general fatigue. Multiple liver masses and Borrmann type 2 gastric tumor were detected. A clinical diagnosis of hepatocellular carcinoma and gastric cancer was made based on the patient's high levels of serum alpha-fetoprotein (AFP; 490 200 ng/mL) and protein induced by vitamin K absence or antagonist-II (PIVKA-II, 2284 mAU/mL). The patient's general condition worsened gradually and she died 42 days after admission. Autopsy revealed that the predominant histological structure of the gastric tumor was trabecular or sheet-like, although a tubular structure was also found. Venous invasion was prominent. Immunohistochemically, the tumor tissue was positive for AFP and a few tumor cells were positive for PIVKA-II. The histological appearance and immunohistochemical features of the hepatic tumors resembled that of the gastric tumor. This case was pathologically diagnosed as AFP- and PIVKA-II-producing gastric carcinoma with multiple liver metastases. When tumors are found in the stomach and liver and serum PIVKA-II level is abnormally high, the possibility of PIVKA-II-producing gastric cancer with liver metastasis should be considered, especially when hepatitis virus markers are negative and liver cirrhosis is not present. | lld:pubmed |
| pubmed-article:12675768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12675768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12675768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12675768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12675768 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12675768 | pubmed:issn | 1320-5463 | lld:pubmed |
| pubmed-article:12675768 | pubmed:author | pubmed-author:TakahashiYosh... | lld:pubmed |
| pubmed-article:12675768 | pubmed:author | pubmed-author:InoueTohruT | lld:pubmed |
| pubmed-article:12675768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12675768 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:12675768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12675768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12675768 | pubmed:pagination | 236-40 | lld:pubmed |
| pubmed-article:12675768 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:meshHeading | pubmed-meshheading:12675768... | lld:pubmed |
| pubmed-article:12675768 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12675768 | pubmed:articleTitle | Des-gamma carboxy prothrombin (PIVKA-II) and alpha-fetoprotein producing gastric cancer with multiple liver metastases. | lld:pubmed |
| pubmed-article:12675768 | pubmed:affiliation | Department of Pathology, Tokyo University Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ytakaha-tky@umin.ac.jp | lld:pubmed |
| pubmed-article:12675768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12675768 | pubmed:publicationType | Case Reports | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12675768 | lld:pubmed |
