| pubmed-article:12672821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C1704928 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C1335864 | lld:lifeskim |
| pubmed-article:12672821 | lifeskim:mentions | umls-concept:C1425409 | lld:lifeskim |
| pubmed-article:12672821 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:12672821 | pubmed:dateCreated | 2003-6-9 | lld:pubmed |
| pubmed-article:12672821 | pubmed:abstractText | Mammalian Enabled (Mena) is a mammalian homologue of Drosophila Enabled (Ena), which genetically interacts with Drosophila Abl tyrosine kinase. The signaling pathway involving c-Abl and Mena (Ena) is not fully understood. To find molecules that participate in the c-Abl/Mena pathway, we searched for Mena-binding proteins using a yeast two-hybrid system. We identified Abl interactor 1 (Abi-1), which is known to interact with c-Abl, as a binding protein for Mena. Binding analysis revealed that the Ena/Vasp homology 1 domain of Mena and the polyproline structure of Abi-1 are necessary for the interaction. The interaction between Mena and Abi-1 was also observed in a mammalian expression system. Importantly, Abi-1 dramatically promoted c-Abl-mediated tyrosine phosphorylation of Mena but not other substrates such as c-Cbl. Mutational analysis demonstrated that the phosphorylation site of Mena is Tyr-296. Our results suggest that Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. | lld:pubmed |
| pubmed-article:12672821 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12672821 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12672821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12672821 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12672821 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:TaniKatsukoK | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:KojimaHiroshi... | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:HanafusaHides... | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:SatoSeiichiS | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:ShishidoTomoy... | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:SukezaneTaiko... | lld:pubmed |
| pubmed-article:12672821 | pubmed:author | pubmed-author:HiroseHidenor... | lld:pubmed |
| pubmed-article:12672821 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12672821 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:12672821 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12672821 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12672821 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12672821 | pubmed:pagination | 21685-92 | lld:pubmed |
| pubmed-article:12672821 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12672821 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12672821 | pubmed:articleTitle | Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase. | lld:pubmed |
| pubmed-article:12672821 | pubmed:affiliation | School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan. tani@ls.toyaku.ac.jp | lld:pubmed |
| pubmed-article:12672821 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12672821 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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