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pubmed-article:12670053pubmed:abstractTextA study was performed to analyze whether local denervation of the medial branch of the dorsal ramus of the lumbar spinal nerve occurs in a patient with postoperative failed-back surgery syndrome/postdiscotomy syndrome (FBSS/PDS). We investigated the effect of the loss of innervation of the multifidus muscle on neuronal nitrite oxide synthetase (n-NOS) and endothelial nitrite oxide synthetase (e-NOS) applying realtime RT-PCR and immunohistochemistry. Our study demonstrates a substantial reduction of n-NOS expression, supporting the view that local denervation of the multifidus is involved in the pathology of FBSS. No regulation of e-NOS was detectable. Interestingly, this change is region-specific and does not occur throughout the entire multifidus segment. This result supports the hypothesis that local denervation of the multifidus muscle is involved in the pathology of FBSS/ PDS.lld:pubmed
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pubmed-article:12670053pubmed:pagination71-7lld:pubmed
pubmed-article:12670053pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:12670053pubmed:articleTitleMolecular evidence for local denervation of paraspinal muscles in failed-back surgery/postdiscotomy syndrome.lld:pubmed
pubmed-article:12670053pubmed:affiliationDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany.lld:pubmed
pubmed-article:12670053pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12670053pubmed:publicationTypeCase Reportslld:pubmed
pubmed-article:12670053pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed