| pubmed-article:12669034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C0214743 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12669034 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:12669034 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12669034 | pubmed:dateCreated | 2003-5-1 | lld:pubmed |
| pubmed-article:12669034 | pubmed:abstractText | Using natural killer T (NKT) cell-deficient mice, we show here that allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma, does not develop in the absence of V(alpha)14i NKT cells. The failure of NKT cell-deficient mice to develop AHR is not due to an inability of these mice to produce type 2 T-helper (Th2) responses because NKT cell-deficient mice that are immunized subcutaneously at non-mucosal sites produce normal Th2-biased responses. The failure to develop AHR can be reversed by the adoptive transfer of tetramer-purified NKT cells producing interleukin (IL)-4 and IL-13 to Ja281(-/-) mice, which lack the invariant T-cell receptor (TCR) of NKT cells, or by the administration to Cd1d(-/-) mice of recombinant IL-13, which directly affects airway smooth muscle cells. Thus, pulmonary V(alpha)14i NKT cells crucially regulate the development of asthma and Th2-biased respiratory immunity against nominal exogenous antigens. Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma. | lld:pubmed |
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| pubmed-article:12669034 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12669034 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12669034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12669034 | pubmed:month | May | lld:pubmed |
| pubmed-article:12669034 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:GrusbyMichael... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:NakayamaToshi... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:TaniguchiMasa... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:KronenbergMit... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:UmetsuDale... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:DeKruyffRosem... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:StockPhilippe... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:AkbariOmidO | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:SidobreStepha... | lld:pubmed |
| pubmed-article:12669034 | pubmed:author | pubmed-author:MeyerEverettE | lld:pubmed |
| pubmed-article:12669034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12669034 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12669034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12669034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12669034 | pubmed:pagination | 582-8 | lld:pubmed |
| pubmed-article:12669034 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12669034 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12669034 | pubmed:articleTitle | Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. | lld:pubmed |
| pubmed-article:12669034 | pubmed:affiliation | Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA. | lld:pubmed |
| pubmed-article:12669034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12669034 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12669034 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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