| pubmed-article:12668061 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12668061 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:12668061 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:12668061 | lifeskim:mentions | umls-concept:C0008525 | lld:lifeskim |
| pubmed-article:12668061 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:12668061 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12668061 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12668061 | pubmed:dateCreated | 2003-4-1 | lld:pubmed |
| pubmed-article:12668061 | pubmed:abstractText | Choroideremia (CHM) is an X-linked retinal degenerative disease resulting from a lack of functional Rab Escort Protein-1 (REP-1). As a first step in developing gene-based therapies for this disease, we evaluated the feasibility of delivering functional REP-1 to defective lymphocytes and fibroblasts isolated from individuals with CHM. A recombinant adenovirus delivering the full-length human cDNA encoding REP-1 under the control of a cytomegalovirus promoter was generated. Adenovirus-mediated delivery of REP-1 rescued the defective cells as assessed through protein and enzymatic assays. Ultimately, it may be possible to use virus-mediated delivery of REP-1 to evaluate disease intervention in vivo. | lld:pubmed |
| pubmed-article:12668061 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12668061 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12668061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12668061 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12668061 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12668061 | pubmed:issn | 0042-6989 | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:SeabraMiguel... | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:AnandVibhaV | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:MaguireAlbert... | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:BennettJeanJ | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:BarralDuarte... | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:ZengYongY | lld:pubmed |
| pubmed-article:12668061 | pubmed:author | pubmed-author:BrunsmannFran... | lld:pubmed |
| pubmed-article:12668061 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12668061 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:12668061 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12668061 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12668061 | pubmed:pagination | 919-26 | lld:pubmed |
| pubmed-article:12668061 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:meshHeading | pubmed-meshheading:12668061... | lld:pubmed |
| pubmed-article:12668061 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12668061 | pubmed:articleTitle | Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. | lld:pubmed |
| pubmed-article:12668061 | pubmed:affiliation | Department of Ophthalmology, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6069, USA. jebennet@mail.med.upenn.edu | lld:pubmed |
| pubmed-article:12668061 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12668061 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12668061 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
