| pubmed-article:12660916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C1261478 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C2709058 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0887947 | lld:lifeskim |
| pubmed-article:12660916 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:12660916 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12660916 | pubmed:dateCreated | 2003-3-27 | lld:pubmed |
| pubmed-article:12660916 | pubmed:abstractText | Mechanisms that underly discordant CD4+ cell/virus load (VL) responses in patients who receive highly active antiretroviral therapy (HAART) were studied in 30 human immunodeficiency virus (HIV)-positive patients, in 3 groups. Discordant responders maintained CD4+ cell levels >200/mm(3) with stable or increasing trend, despite sustained VLs of 500-5000 copies/mL, for >2 years. Treatment-success patients had CD4+ cell counts >200/mm(3) with stable or increasing trend and VLs <50 copies/mL, for >2 years. Treatment-failure patients initially responded to HAART, followed by decreasing CD4+ cell counts and increasing VLs. Interferon-gamma production to gag and noncytolytic CD8+ cell suppressive activity were greater in discordant responders. Cellular activation was greatest in patients with treatment failure. All discordant responders had non-syncytium-inducing (CCR5-tropic) viruses. Viruses from discordant responders and from patients with treatment failure had extensive resistance mutations; discordant responders had significantly lower viral replication capacities. These findings suggest that discordant responses may be related to enhanced HIV-directed immune responses, diminished cellular activation, decreased viral replication capacity, and preservation of non-syncytium-inducing virus strains. | lld:pubmed |
| pubmed-article:12660916 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12660916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12660916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12660916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12660916 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12660916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12660916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12660916 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12660916 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:SempowskiGreg... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:StaatsHerman... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:FerrariGuidoG | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:PatelDhavalku... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:WrinTerriT | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:HellmannNicho... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:FiscusSusan... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:HicksCharles... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:SufkaSusan... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:GryszowkaVict... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:TomarasGeorgi... | lld:pubmed |
| pubmed-article:12660916 | pubmed:author | pubmed-author:WeinholdKent... | lld:pubmed |
| pubmed-article:12660916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12660916 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12660916 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:12660916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12660916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12660916 | pubmed:pagination | 1027-37 | lld:pubmed |
| pubmed-article:12660916 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:meshHeading | pubmed-meshheading:12660916... | lld:pubmed |
| pubmed-article:12660916 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12660916 | pubmed:articleTitle | Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control. | lld:pubmed |
| pubmed-article:12660916 | pubmed:affiliation | Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. | lld:pubmed |
| pubmed-article:12660916 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12660916 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12660916 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12660916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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