Linked Life Data

12660880

Source:http://linkedlifedata.com/resource/pubmed/id/12660880

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pubmed-article:12660880pubmed:dateCreated2003-3-27lld:pubmed
pubmed-article:12660880pubmed:abstractTextResistin is a recently discovered hormone that is exclusively expressed in adipose tissue. Its expression in rodents was reported to be elevated or suppressed in genetic and diet-induced obesity, respectively. Resistin treatment impaired glucose tolerance and insulin action. Immunoneutralization of resistin improved insulin sensitivity, while thiazolidinedione treatment reduced resistin expression. Therefore, resistin could play a critical role in the development of obesity and type 2 diabetes. In this study were determined resistin plasma levels in humans suffering from type 1 and type 2 diabetes and in healthy controls. Plasma levels of resistin in healthy controls were 38.78 ng/ml. They were not statistically different in individuals with a broad BMI range. Resistin plasma levels in type 2 diabetes were 38.7 ng/ml, and 39.4 ng/ml in type 1 diabetes. Thiazolidinedione treatment did not influence resistin plasma levels. We conclude from our data: 1. resistin can be detected in human plasma, 2. plasma resistin levels are not different in type 1 and type 2 diabetes.lld:pubmed
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pubmed-article:12660880pubmed:dateRevised2009-2-19lld:pubmed
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pubmed-article:12660880pubmed:articleTitlePlasma resistin levels in patients with type 1 and type 2 diabetes mellitus and in healthy controls.lld:pubmed
pubmed-article:12660880pubmed:affiliationPractice for Internal Medicine, Marburg, Germany. C.Fehmann@web.delld:pubmed
pubmed-article:12660880pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:12660880pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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