pubmed-article:12660573 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C0007758 | lld:lifeskim |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C0206042 | lld:lifeskim |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C1418941 | lld:lifeskim |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C1513380 | lld:lifeskim |
pubmed-article:12660573 | lifeskim:mentions | umls-concept:C1533148 | lld:lifeskim |
pubmed-article:12660573 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:12660573 | pubmed:dateCreated | 2003-3-27 | lld:pubmed |
pubmed-article:12660573 | pubmed:abstractText | We report the fifth French case of fatal familial insomnia, characterized by a mutation at codon 178 of prion protein gene and by heterozygoty (Met/Val) at codon 129. The clinical picture included cerebellar ataxia, dysautonomia and frontal lobe syndrome. Prion protein gene analysis was performed in order to support a diagnosis of Creutzfeldt-Jakob disease and assert the diagnosis of fatal familial insomnia. Neuropathologic analysis showed unusual changes including severe neuronal loss in the inferior olive and the dentate nucleus, and absence of obvious lesions in the thalamus. Moreover, spongiform changes were moderate in the superior temporal cortex and the occipital cortex. There was no spongiform change in frontal cortex. Abnormal prion protein (PrP(res)) was mainly evidenced in the parietal cortex. Molecular genetic study of the PRNP gene should be performed in patients who present with a cerebellar ataxia of equivocal origin. | lld:pubmed |
pubmed-article:12660573 | pubmed:language | fre | lld:pubmed |
pubmed-article:12660573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12660573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12660573 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12660573 | pubmed:month | Feb | lld:pubmed |
pubmed-article:12660573 | pubmed:issn | 0035-3787 | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:VincentDD | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:BeaudryPP | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:HauwJ JJJ | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:JungPP | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:DegosC FCF | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:VitalAA | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:LatinvilleDD | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:LaplancheJ... | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:DefontainesBB | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:SazdovitchVV | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:MarcaudVV | lld:pubmed |
pubmed-article:12660573 | pubmed:author | pubmed-author:VecchieriniFF | lld:pubmed |
pubmed-article:12660573 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12660573 | pubmed:volume | 159 | lld:pubmed |
pubmed-article:12660573 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12660573 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12660573 | pubmed:pagination | 199-202 | lld:pubmed |
pubmed-article:12660573 | pubmed:dateRevised | 2006-11-28 | lld:pubmed |
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pubmed-article:12660573 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:12660573 | pubmed:articleTitle | [Usefulness of molecular genetic analysis of the PRNP gene in patients with cerebellar ataxia: a new case of fatal familial insomnia]. | lld:pubmed |
pubmed-article:12660573 | pubmed:affiliation | Service de Neurologie, Hôpital Saint-Joseph, Paris. | lld:pubmed |
pubmed-article:12660573 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12660573 | pubmed:publicationType | English Abstract | lld:pubmed |
pubmed-article:12660573 | pubmed:publicationType | Case Reports | lld:pubmed |
pubmed-article:12660573 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |