| pubmed-article:12660174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:12660174 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:12660174 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12660174 | pubmed:dateCreated | 2003-3-27 | lld:pubmed |
| pubmed-article:12660174 | pubmed:abstractText | Telomeric DNA usually consists of a repetitive sequence: C(1-3)A/TG(1-3) in yeast, and C(3)TA(2)/T(2)AG(3) in vertebrates. In yeast, the sequence-specific DNA- binding protein Rap1p is thought to be essential for telomere function. In a tlc1h mutant, the templating region of the telomerase RNA gene is altered so that telomerase adds the vertebrate telomere sequence instead of the yeast sequence to the chromosome end. A tlc1h strain has short but stable telomeres and no growth defect. We show here that Rap1p and the Rap1p-associated Rif2p did not bind to a telomere that contains purely vertebrate repeats, while the TG(1-3) single-stranded DNA binding protein Cdc13p and the normally non-telomeric protein Tbf1p did bind this telomere. A chromosome with one entirely vertebrate-sequence telomere had a wild-type loss rate, and the telomere was maintained at a short but stable length. However, this telomere was unable to silence a telomere-adjacent URA3 gene, and the strain carrying this telomere had a severe defect in meiosis. We conclude that Rap1p localization to a C(3)TA(2) telomere is not required for its essential mitotic functions. | lld:pubmed |
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| pubmed-article:12660174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12660174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12660174 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12660174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12660174 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12660174 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:12660174 | pubmed:author | pubmed-author:ZakianVirgini... | lld:pubmed |
| pubmed-article:12660174 | pubmed:author | pubmed-author:AlexanderMary... | lld:pubmed |
| pubmed-article:12660174 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12660174 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12660174 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12660174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12660174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12660174 | pubmed:pagination | 1688-96 | lld:pubmed |
| pubmed-article:12660174 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:12660174 | pubmed:meshHeading | pubmed-meshheading:12660174... | lld:pubmed |
| pubmed-article:12660174 | pubmed:meshHeading | pubmed-meshheading:12660174... | lld:pubmed |
| pubmed-article:12660174 | pubmed:meshHeading | pubmed-meshheading:12660174... | lld:pubmed |
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| pubmed-article:12660174 | pubmed:meshHeading | pubmed-meshheading:12660174... | lld:pubmed |
