| pubmed-article:12657269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12657269 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12657269 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12657269 | pubmed:dateCreated | 2003-3-26 | lld:pubmed |
| pubmed-article:12657269 | pubmed:abstractText | A novel series of 2-(3-indolyl)alkylamino-1-(3-chlorophenyl)ethanols was prepared and evaluated for in vitro ability to stimulate cAMP production in Chinese hamster ovary cells expressing cloned human beta(3)-AR. The optically active 30a was found to be the most potent and selective human beta(3)-AR agonist in this series with an EC(50) value of 0.062nM. In addition, 30a selectivity for human beta(3)-AR was 210-fold and 103-fold that for human beta(2)-AR and beta(1)-AR, respectively. Furthermore, 30a showed potent agonistic activity at rat beta(3)-AR. | lld:pubmed |
| pubmed-article:12657269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12657269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12657269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12657269 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12657269 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:KatoShiroS | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:SuzukiKenjiK | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:HaradaHiroshi... | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:YoshidaNaoyuk... | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:HirokawaYoshi... | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:KawashimaHito... | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:HiyamaYoichiY | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:OueMayumiM | lld:pubmed |
| pubmed-article:12657269 | pubmed:author | pubmed-author:FurutaniYasuj... | lld:pubmed |
| pubmed-article:12657269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12657269 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:12657269 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12657269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12657269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12657269 | pubmed:pagination | 1301-5 | lld:pubmed |
| pubmed-article:12657269 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
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| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
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| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
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| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:meshHeading | pubmed-meshheading:12657269... | lld:pubmed |
| pubmed-article:12657269 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12657269 | pubmed:articleTitle | Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines. | lld:pubmed |
| pubmed-article:12657269 | pubmed:affiliation | Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki, Suita, Japan. hiroshi-harada@dainippon-pharm.co.jp | lld:pubmed |
| pubmed-article:12657269 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12657269 | lld:chembl |
