| pubmed-article:12653580 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C0019625 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C0019621 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C0007577 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C1335205 | lld:lifeskim |
| pubmed-article:12653580 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:12653580 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12653580 | pubmed:dateCreated | 2003-3-25 | lld:pubmed |
| pubmed-article:12653580 | pubmed:abstractText | Context.-We investigated expression of the adhesion molecule CD31 in sinus histiocytosis with massive lymphadenopathy (SHML) and Langerhans cell histiocytosis (LCH) because (1) SHML and LCH cells express a variety of cellular adhesion molecules and (2) SHML has been characterized as a reactive histiocytic proliferation, and tissue macrophages (histiocytes) are known to express CD31. Objective.-The purpose of this study was to determine whether SHML and LCH cells express CD31 and whether dual staining with CD31 and S100 facilitates diagnosis of these disease states. Methods.-Formalin-fixed, paraffin-embedded archival tissues were immunohistochemically stained via the labeled streptavidin-biotin method using antibodies against CD31 and S100 protein after heat-induced epitope retrieval. Archival tissues included SHML (n = 2), LCH (n = 10), malignant melanoma (n = 5), sinus hyperplasia (n = 4), granulomas (n = 4), granular cell tumor (n = 6), and normal skin (n = 4). Results.-Normal Langerhans cells in the epidermis were CD31(-)/S100(+); neoplastic Langerhans cells in LCH were CD31(+)/S100(+). Histiocytes in granulomas and in sinus hyperplasia were CD31(+)/S100(-); abnormal histiocytes in SHML were CD31(+)/S100(+). S100(+) tumors (malignant melanoma and granular cell tumor) were CD31(-). Conclusions.-The spectrum of cell types that express CD31 is expanded to include SHML and LCH. We speculate that up-regulation of CD31 in neoplastic Langerhans cells contributes to the migratory capability of LCH cells. CD31 may be a useful nonlysosomal marker of macrophages and their neoplastic counterparts (true histiocytic sarcomas). An immunohistochemical staining panel that includes CD31 and S100 facilitates the diagnosis of SHML and LCH. | lld:pubmed |
| pubmed-article:12653580 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12653580 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12653580 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12653580 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12653580 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12653580 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12653580 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12653580 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12653580 | pubmed:issn | 1543-2165 | lld:pubmed |
| pubmed-article:12653580 | pubmed:author | pubmed-author:SloneStephen... | lld:pubmed |
| pubmed-article:12653580 | pubmed:author | pubmed-author:BuchinoJohn... | lld:pubmed |
| pubmed-article:12653580 | pubmed:author | pubmed-author:FlemingDonald... | lld:pubmed |
| pubmed-article:12653580 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12653580 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:12653580 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12653580 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12653580 | pubmed:pagination | 341-4 | lld:pubmed |
| pubmed-article:12653580 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:meshHeading | pubmed-meshheading:12653580... | lld:pubmed |
| pubmed-article:12653580 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12653580 | pubmed:articleTitle | Sinus histiocytosis with massive lymphadenopathy and Langerhans cell histiocytosis express the cellular adhesion molecule CD31. | lld:pubmed |
| pubmed-article:12653580 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, School of Medicine, University of Louisville, Louisville, KY 40292, USA. spslon01@gwise.louisville.edu | lld:pubmed |
| pubmed-article:12653580 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:5175 | entrezgene:pubmed | pubmed-article:12653580 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12653580 | lld:entrezgene |
| lhgdn:association:9576 | lhgdn:found_in | pubmed-article:12653580 | lld:lhgdn |
